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PHARM 203 (Final) > Anaesthetics (Drugs) > Flashcards

Anaesthetics (Drugs) Flashcards

1
Q

Morphine

A

Opioid Agonist
–> Anti-nociceptive

MOA:
- Opens K+ Channels
- Inhibits VGCC
–> Hyperpolarization of Pain Neurons

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2
Q

Diamorphine

A

Opioid Agonist
–> Anti-nociceptive

MOA:
- Opens K+ Channels
- Inhibits VGCC
–> Hyperpolarization of Pain Neurons

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3
Q

Codeine

A

Opioid Agonist
–> Anti-nociceptive

MOA:
- Opens K+ Channels
- Inhibits VGCC
–> Hyperpolarization of Pain Neurons

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4
Q

Oxycodone

A

Opioid Agonist
–> Anti-nociceptive

MOA:
- Opens K+ Channels
- Inhibits VGCC
–> Hyperpolarization of Pain Neurons

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5
Q

Methadone

A

Opioid Agonist
–> Anti-nociceptive

MOA:
- Opens K+ Channels
- Inhibits VGCC
–> Hyperpolarization of Pain Neurons

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6
Q

Buprenorphine

A

Partial Opioid Agonist
–> Anti-nociceptive

MOA:
- Opens K+ Channels
- Inhibits VGCC
–> Hyperpolarization of Pain Neurons

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7
Q

Fentanyl

A

Opioid Agonist
–> Anti-nociceptive

MOA:
- Opens K+ Channels
- Inhibits VGCC
–> Hyperpolarization of Pain Neurons

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8
Q

Acetylsalicylic Acid

A

NSAID
–> Analgesic, Antipyretic, Anti-Inflammation

MOA:
- Inhibit COX-1 and COX-2
–> Inhibit Prostaglandin Generation
–> Inhibits pain-producing effects

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9
Q

Ibuprofen

A

NSAID
–> Analgesic, Antipyretic, Anti-Inflammation

MOA:
- Inhibit COX-1 and COX-2
–> Inhibit Prostaglandin Generation
–> Inhibits pain-producing effects

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10
Q

Acetaminophen (Paracetamol)

A

Analgesic, Antipyretic
No Anti-Inflammation

MOA:
- Unknown
- COX-3?
- Activate and desensitize TRPA1/V1 Channels in brain?

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11
Q

Amitriptyline

A

Tricyclic Antidepressant
–> Relieves Neuropathic Pain

MOA:
- Inhibits NE reuptake
–> NE reduces pain

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12
Q

Nortryptaline

A

Tricyclic Antidepressant
–> Relieves Neuropathic Pain

MOA:
- Inhibits NE reuptake
–> NE reduces pain

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13
Q

Desipramine

A

Tricyclic Antidepressant
–> Relieves Neuropathic Pain

MOA:
- Inhibits NE reuptake
–> NE reduces pain

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14
Q

Gabapentin

A

Antiepileptic Drug
–> Relieves Neuropathic Pain

MOA:
- Reduces expression of VGCC
- Blocks VGSC
–> Less stimulation

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15
Q

Carbamazepine

A

Antiepileptic Drug
–> Relieves Neuropathic Pain

MOA:
- Reduces expression of VGCC
- Blocks VGSC
–> Less stimulation

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16
Q

Nefopam

A

Analgesic

MOA:
- Inhibits amine uptake
- Blocks Na+ Channels

17
Q

Ziconotide

A

Analgesic

MOA:
- N-Type Ca2+ Channel Blocker

18
Q

Nabiximols (Sativex)

A

Analgesic (THC and Cannabidiol)

MOA:
- Stimulation of CB1/CB2 Receptors

PHARM 203 (Final) (41 decks)

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