Angina (Drugs)

Question 1

Nicorandil

Answer 1

Dual Action
- Treats Angina

MOA:
Nitrate Like Effect:
- Dilate Coronary Arteries
–> Increase Supply
- Venodilation, Reduce preload
–> Decrease Demand

K+ Channel Opener:
- Dilate Peripheral Arterioles, Decrease Afterload
–> Decrease Demand
- Dilate Coronary Resistance Vessels
–> Increase Supply

Question 2

Ivabradine

Answer 2

Inhibits funny channels

Question 3

Ranolazine

Question 4

Nitric Oxides

Answer 4

1. Activates GC
2. GC converts GTP into cGMP
3. cGMP dephosphorylates MLC
   - Promotes MLCP
   - Also reduces Ca2+
4. Relaxation of SMC

Question 5

bAR

Answer 5

1. Activates Gs
2. Promotes AC
3. Increases cAMP
4. Inhibits MLCK
5. Promotes relaxation

Question 6

Nitrate

Answer 6

Dilates collateral vessels
- Redistributes blood flow to ischemic areas

Question 7

Dipyridamole

Answer 7

Dilates blood vessels (Does not dilate collateral vessels)
- Blood flow distributed to normal area
- Blood flow to ischemic area is reduced

• Not used for Ischemic Attack
• Treats hypertension