Stimulants & Psychotomimetics (Drugs)

Question 1

Amphetamine

Answer 1

Stimulant (Drug of Abuse)

MOA:
- Inhibit DAT and NET
- Displace endogenous monoamines (Vesicles–>Cytoplasm)
- DAT and NET work in reverse
- At high concentrations inhibit MAO
–> Increase DA and NE in brain

Question 2

Dextroamphetamine

Answer 2

Stimulant
- Used to treat ADHD

Question 3

Mephedrone

Answer 3

Stimulant - Similar to Amphetamine

MOA:
- Inhibit DA and 5-HT reuptake
- Enhance DA and 5-HT release
–> Increase DA and 5-HT in brain

Question 4

Methylphenidate (Ritalin)

Answer 4

Stimulant - Similar to Amphetamine
- Treats narcolepsy, ADHD

MOA:
- Inhibits NET and DAT on neuronal plasma membrane
- Inhibits SERT (Lower Porency)
–> Increases NA and DA

Question 5

Modafinil

Answer 5

Stimulant
- Treat Narcolepsy

MOA:
- Inhibits DAT
- Has other CNS effects

Question 6

Cocaine

Answer 6

Stimulant
- Local Anaesthetic and Drug of Abuse

MOA:
- Blocks NET, DAT, and SERT on nerve terminals

Question 7

Methylxanthines

Answer 7

Stimulant (AKA Caffeine and Theophylline)
- Mild CNS Stimulant

MOA:
- A2 Receptor Antagonist
–> Prevents CNS inhibition

Question 8

Lysergic Acid Diethylamide

Answer 8

Psychomimetic (AKA LSD )
- 5-HT2A Agonist

MOA:
- Binds 5-HT2A receptors in brain

Question 9

Psilocybin

Answer 9

Psychomimetic - Effects similar to LSD
- 5-HT2A Agonist

MOA:
- Binds 5-HT2A in brain

Question 10

MDMA

Answer 10

Psychomimetic - AKA Ecstasy

MOA:
- 5-HT reuptake inhibitor (Psychomimetic)
- DA, NA reuptake inhibitor (Euphoria/Dysphoria)

Small doses can lead to overdose

Question 11

Mescaline

Answer 11

Psychomimetic
- Phenylamine Structure (Similar to amphetamine)

MOA:
5-HT Signaling?

Question 12

Ketamine (Special K)

Answer 12

Psychomimetic
NMDA Receptor Blocker

Question 13

Phencyclidine (PCP)

Answer 13

Psychomimetic
NMDA Receptor Blocker