Antidepressants (Drugs) Flashcards
St John’s Wort
Conventional Antidepressant
MOA:
5-HT and NE Reuptake Inhibitors
Citalopram
SSRI
- Antidepressant
MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin
Also blocks H1 (Medium)
QT Interval Prolongation
Escitalopram
SSRI
- Antidepressant
MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin
Also blocks H1 (Weak)
Fluvoxamine
SSRI
- Antidepressant
MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin
Also blocks NE reuptake
Paroxetine
SSRI
- Antidepressant
MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin
Also blocks NE reuptake
Fluoxetine
SSRI
- Antidepressant
MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin
Also blocks NE reuptake
Sertraline
SSRI
- Antidepressant
MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin
Also blocks DA reuptake
Vortioxetine
SSRI: Serotonin Modulator and Stimulator
- Antidepressant
MOA:
5-HT Reuptake Inhibitor
5-HT1A Agonist and 5-HT1B Agonist
5-HT3 Antagonist
Specificity and Antagonism allows for lower side effects
Vilazodone
SSRI
- Antidepressant
MOA:
Serotonin Reuptake Inhibitor
5-HT1A Agonist
Desipramine
TCA (Secondary Amine)
- Antidepressant
MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for NE > 5-HT)
Also affects mAchR, H1, and 5-HT receptors
Nortriptyline
TCA (Secondary Amine)
- Antidepressant
MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for NE > 5-HT)
Also affects mAchR, H1, and 5-HT receptors
Amitriptyline
TCA (Tertiary Amine)
- Antidepressant
MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)
Also affects mAchR, H1, and 5-HT receptors
Clomipramine
TCA (Tertiary Amine)
- Antidepressant
MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)
Also affects mAchR, H1, and 5-HT receptors
Doxepin
TCA (Tertiary Amine)
- Antidepressant
MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)
Also affects mAchR, H1, and 5-HT receptors
Imipramine
TCA (Tertiary Amine)
- Antidepressant
MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)
Also affects mAchR, H1, and 5-HT receptors
Trimipramine
TCA (Tertiary Amine)
- Antidepressant
MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)
Also affects mAchR, H1, and 5-HT receptors
Venlafaxine
SNRI - Non-selective for 5-HT and NE uptake inhibition
- Antidepressant
MOA:
- At low doses inhibits 5-HT reuptake
- At high doses inhibits NE reuptake
Bupropion
NDRI - NA and DA reuptake inhibitor
- Antidepressant
MOA:
- Nicotinic Ach receptor antagonist
- Inhibits NE and DA reuptake
Makes it easier to get seizure, helps with quitting smoking
Trazodone
Serotonin antagonist and reuptake inhibitors
(SARI)
- Antidepressant
MOA:
- Blocks 5-HT2A and 5-HT2C receptors
- Blocks 5-HT reuptake
Mirtazapine
NASSA
- Antidepressant
MOA:
- Blocks alpha2 adrenoceptor
- Blocks 5-HT2C receptor
–> Enhance NA and 5-HT release
H1 Antagonist (Sedating side effects)
Blocks 5-HT2A and 5-HT3
–> Less sexual dysfunction
Phenelzine
Monoamine Oxidase Inhibitor
(Irreversible Non-Specific)
- Antidepressant
MOA:
- Inhibits MAO
–> Less degradation of 5-HT and NE
Tranylcypromine
Monoamine Oxidase Inhibitor
(Irreversible Non-Specific)
- Antidepressant
MOA:
- Inhibits MAO
–> Less degradation of 5-HT and NE
Moclobemide
Monoamine Oxidase Inhibitor
(Reversible MAO-A Specific )
- Antidepressant
MOA:
- Inhibits MAO
–> Less degradation of 5-HT and NE
Ketamine
NMDA Receptor Blocker
- Antidepressant
Rapid Acting Antidepressant
(Does not increase NE)
