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PHARM 203 (Final) > Antidepressants (Drugs) > Flashcards

Antidepressants (Drugs) Flashcards

1
Q

St John’s Wort

A

Conventional Antidepressant

MOA:
5-HT and NE Reuptake Inhibitors

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2
Q

Citalopram

A

SSRI
- Antidepressant

MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin

Also blocks H1 (Medium)

QT Interval Prolongation

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3
Q

Escitalopram

A

SSRI
- Antidepressant

MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin

Also blocks H1 (Weak)

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4
Q

Fluvoxamine

A

SSRI
- Antidepressant

MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin

Also blocks NE reuptake

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5
Q

Paroxetine

A

SSRI
- Antidepressant

MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin

Also blocks NE reuptake

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6
Q

Fluoxetine

A

SSRI
- Antidepressant

MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin

Also blocks NE reuptake

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7
Q

Sertraline

A

SSRI
- Antidepressant

MOA:
- Blocks 5-HT Reuptake
–> Increase Serotonin

Also blocks DA reuptake

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8
Q

Vortioxetine

A

SSRI: Serotonin Modulator and Stimulator
- Antidepressant

MOA:
5-HT Reuptake Inhibitor
5-HT1A Agonist and 5-HT1B Agonist
5-HT3 Antagonist

Specificity and Antagonism allows for lower side effects

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9
Q

Vilazodone

A

SSRI
- Antidepressant

MOA:
Serotonin Reuptake Inhibitor
5-HT1A Agonist

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10
Q

Desipramine

A

TCA (Secondary Amine)
- Antidepressant

MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for NE > 5-HT)

Also affects mAchR, H1, and 5-HT receptors

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11
Q

Nortriptyline

A

TCA (Secondary Amine)
- Antidepressant

MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for NE > 5-HT)

Also affects mAchR, H1, and 5-HT receptors

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12
Q

Amitriptyline

A

TCA (Tertiary Amine)
- Antidepressant

MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)

Also affects mAchR, H1, and 5-HT receptors

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13
Q

Clomipramine

A

TCA (Tertiary Amine)
- Antidepressant

MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)

Also affects mAchR, H1, and 5-HT receptors

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14
Q

Doxepin

A

TCA (Tertiary Amine)
- Antidepressant

MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)

Also affects mAchR, H1, and 5-HT receptors

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15
Q

Imipramine

A

TCA (Tertiary Amine)
- Antidepressant

MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)

Also affects mAchR, H1, and 5-HT receptors

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16
Q

Trimipramine

A

TCA (Tertiary Amine)
- Antidepressant

MOA:
- Inhibits 5-HT and NE Reuptake
(Greater specificity for 5-HT > NE)

Also affects mAchR, H1, and 5-HT receptors

17
Q

Venlafaxine

A

SNRI - Non-selective for 5-HT and NE uptake inhibition
- Antidepressant

MOA:
- At low doses inhibits 5-HT reuptake
- At high doses inhibits NE reuptake

18
Q

Bupropion

A

NDRI - NA and DA reuptake inhibitor
- Antidepressant

MOA:
- Nicotinic Ach receptor antagonist
- Inhibits NE and DA reuptake

Makes it easier to get seizure, helps with quitting smoking

19
Q

Trazodone

A

Serotonin antagonist and reuptake inhibitors
(SARI)
- Antidepressant

MOA:
- Blocks 5-HT2A and 5-HT2C receptors
- Blocks 5-HT reuptake

20
Q

Mirtazapine

A

NASSA
- Antidepressant

MOA:
- Blocks alpha2 adrenoceptor
- Blocks 5-HT2C receptor
–> Enhance NA and 5-HT release

H1 Antagonist (Sedating side effects)
Blocks 5-HT2A and 5-HT3
–> Less sexual dysfunction

21
Q

Phenelzine

A

Monoamine Oxidase Inhibitor
(Irreversible Non-Specific)
- Antidepressant

MOA:
- Inhibits MAO
–> Less degradation of 5-HT and NE

22
Q

Tranylcypromine

A

Monoamine Oxidase Inhibitor
(Irreversible Non-Specific)
- Antidepressant

MOA:
- Inhibits MAO
–> Less degradation of 5-HT and NE

23
Q

Moclobemide

A

Monoamine Oxidase Inhibitor
(Reversible MAO-A Specific )
- Antidepressant

MOA:
- Inhibits MAO
–> Less degradation of 5-HT and NE

24
Q

Ketamine

A

NMDA Receptor Blocker
- Antidepressant
Rapid Acting Antidepressant
(Does not increase NE)

PHARM 203 (Final) (41 decks)

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