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PHARM 203 (Final) > Antiseizure (Drugs) > Flashcards

Antiseizure (Drugs) Flashcards

1
Q

Phenobarbital

A

GABA Modulator
- Antiseizure

MOA:
Enhances GABA Receptor

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2
Q

Benzodiazepines

A

GABA Modulator
- Antiseizure

MOA:
Enhances GABA Receptor

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3
Q

Tiagabine

A

GABA Modulator
- Antiseizure

MOA:
Inhibits GABA transporter (GAT1)
–> Inhibits GABA Re-uptake

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4
Q

Vigabatrin

A

GABA Modulator
- Antiseizure

MOA:
Irreversible Inhibitor of GABA Transaminase
- Inhibits GABA breakdown

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5
Q

Pregabalin

A

GABA Modulator
- Antiseizure

MOA:
- P/Q Type Calcium Channel
–> Modulates release of neurotransmitters like GABA

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6
Q

Gabapentin

A

GABA Modulator
- Antiseizure

MOA:
- P/Q Type Calcium Channel
–> Modulates release of neurotransmitters like GABA

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7
Q

Phenytoin

A

Sodium Channel Blocker
- Antiseizure

MOA:
- Prolongs refractory period of inactivated sodium channels
–> Decrease firing of Na+ Channels

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8
Q

Carbamazepine

A

Sodium Channel Blocker
- Antiseizure

MOA:
- Prolongs refractory period of inactivated sodium channels
–> Decrease firing of Na+ Channels

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9
Q

Lacosamide

A

Sodium Channel Blocker
- Antiseizure

MOA:
- Prolongs refractory period of inactivated sodium channels
–> Decrease firing of Na+ Channels

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10
Q

Lamotrigine

A

Sodium Channel Blocker
- Antiseizure

MOA:
- Prolongs refractory period of inactivated sodium channels
–> Decrease firing of Na+ Channels

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11
Q

Zonisamide

A

Sodium Channel Blocker
- Antiseizure

MOA:
- Prolongs refractory period of inactivated sodium channels
–> Decrease firing of Na+ Channels

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12
Q

Ethosuximide

A

T-Type Calcium Channel Blocker
- Antiseizure

MOA:
- Prevents hyperactivity of T-Type Calcium Channels
–> Prevents absence seizures

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13
Q

Valproic Acid

A

T-Type Calcium Channel Blocker
- Antiseizure

MOA:
- Prevents hyperactivity of T-Type Calcium Channels
–> Prevents absence seizures

Also has other mechanisms of actions
–> (Broad Spectrum)

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14
Q

Levetiracetam

A

SV2A
- Antiseizure

MOA:
- Binds to Synaptic Vesicle Protein 2A
–> Modulates Neurotransmitter release
(Broad Spectrum)

Increased Release of GABA
Decreased Release of Glutamate

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15
Q

Brivaracetam

A

SV2A
- Antiseizure

MOA:
- Binds to Synaptic Vesicle Protein 2A
–> Modulates Neurotransmitter release
(Broad Spectrum)

Increased Release of GABA
Decreased Release of Glutamate

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16
Q

Perampanel

A

Non-competitive AMPA-Receptor Antagonist
- Antiseizure

MOA:
- Prevents action of excitatory AMPA receptors

17
Q

Topiramate

A

Broad Spectrum
- Antiseizure

MOA:
- Multiple Mechanisms of action

18
Q

Felbamate

A

Broad Spectrum
- Antiseizure

MOA:
- Multiple Mechanisms of action

PHARM 203 (Final) (41 decks)

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