Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

STEP 1 > vasculidities > Flashcards

vasculidities Flashcards

1
Q

what are the key features of microscopic polyangitis

A
  • affects kidneys
  • causes pauci-immune crescentic glomerulonephritis
  • p-ANCA+
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is p-ANCA? What is the antigen and what is the antibody?

A

perinuclear anti-neurophil cytoplasmic antibodies

antigen is myeloperoxidase
antibody is MPO-ANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is c-ANCA? What is the antigen and what is the antibody?

A

cytoplasmic anti-nutrophil cytoplasmic antibodies

antigen is proteinase 3 (PR3)
antibody is PR3-ANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the key features of granulomatosis with polyangitis

A

focal necrotizing vasculitis with granulomas in the lung and upper airway
glomerulonephritis
c-ANCA

NOTE:differentiate from goodpastures by involvement of upper airway in wegners

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the treatment for granulomatosis with polyangitis?

A

cyclophosphamide and corticosteroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the key features of churg-strauss syndome?

A

granulomatosis with eosinophilia (multinucleated giant cells with eosinophils) and ASTHMA/sinusitis/skin lesions/peripheral neuropathy (foot drop/wrist drop)
+pANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the key features of henoch-schonlein purpura?

A

most-common form of systemic vasculitis in childhood

  • rash on buttocks and legs made up of PALPABLE PUPURA
  • arthralgias (knees)
  • abdominal pain with melana(intestinal hemorrhage)
  • renal disease (deposition of IgA immune complexes - IgA nephropathy) with nephritic hematuria

OFTEN OCCURS FOLLOWING UPPER RESPIRATORY INFECTION (IgA nephropathy)!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are the key features of polyarteritis nodosa?

A

medium vessel vasculitis that involves kidneys and visceral organs but spares lungs - can have abdominal pain melana, myalgia

associiated with hepB/hepC

NEGATIVE FOR ANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is mucocutaneous lymph node syndrome?

A

kawasaki’s disease
necrotizing vasculitis seen in asiean infants
fever that lasts >5 days + CRASH symptoms

conjunctuvitis
rash on trunk
adenopathy
strawberry tounge
hands and feet - erythematous desquamation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is a major concern for kawasaki diase?

A

coronary aneurism

can lead to thrombosis and MI

be prepared to make ID from coronary angiogram

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is treatment for kawasaki disease?

A

IV immunoglobulin (goal is to flood system with immunoglobulin and cause feedback-suppression of immune responses to decrease production of auto-antibodies) and asprin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is another name for Burger disease?

A

thromboangiitis obliterans

vasculitis of medium arteries seen in male smokers in their 40’s

intermittent claudication
superficial nodular phlebitis
can lead to gangreen in fingers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is another name for giant cell arteritis?

A

temporal arteritis

affects branches of EXTERNAL carotid arteries (e.g. temporal arteries)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

who is predominantly affected by temporal arteritis? what is the classic presentation?

A

classicly presents in elderly women as unilateral headache with jaw-claudication
occlusion of opthalmic artery can lead to vision loss or irriversible blindness

may have palpable temporal artery

may also have polymyalgia rhumatica (muscle and joint pain)

dx is with temporal artery biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

pt presents with unilateral headache and jaw pain with chewing and elevated ESR. What is Dx?

A

temporal arteritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what’s another name for takiyatsi disease?

A

pulseless disease

due to granulomatous inflamation of arteries of the aortic arch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the key features of takiyatsi arteritis?

A

young asian women in teen

poor pulses in extemities

granulomatous inflamation of arteries of the aortic arch

elevated sed rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

vasculitis is 2 year old asian female

A

kawasaki

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

vasculitis in 20 year old asean female

A

takiyatsu

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

vasculitis associated with asthma

A

churg strause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

most likely vasculitis in young male smoker

A

burger (thromboarteritis obliterans)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

vasculitis associated with polymylagia rheumatica

A

temporal arteritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

vasculitis associated with IgA nephropatrhy

A

henoch-schloch purpura

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

vasculitis associated with Hep B

A

polyarteritis nodosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

vasculitis associated with jaw claudication and vision loss

A

temporal/giant cell arteritis

26
Q

vasculitis associated with strawberry tongue

A

kawasaki’s disease

27
Q

vasculitis associated with desquamation of hands/feet

A

kawasaki’s disease

28
Q

vasculitis associated with poor pulses in the arms

A

takiyasu arteritis

29
Q

vasculitis associated with palpable purpura on the legs

A

henoch-schlochen purpura

30
Q

vasculitis associated with kidney and GI involvement but spares the lungs

A

polyarteruitis nodosa

HEPATITIS!!!

31
Q

vasculitis of the kidney, upper airway and lungs

A

granulomatosis with polyangitis

32
Q

what’s the treatment for renauds?

A

dihydropyridine calcium channel blockers (e.g. nefidipine)

33
Q

what is sturge weber disease?

A

congential disorder that affects capillaries causing AV malformation

princply presents as leptomeningeal angioma

purplish port-wine stain along opthalmic division of trigeminal nerve

associated with seizures, glocoma, tardism

34
Q

what is a strawberry hemangioma?

A

benign hemanioma of cutaneous suface of capillaries seen in infants - spontaneous regresses in childhood (gone by age 8)

35
Q

what is a cherry hemanioma?

A

benign hemanioma of cutaneous surface capillaries - does not regress very common on most people

36
Q

what is a pyogenic granulmoma>

A

raised capillary hemanioma associated with trauam and pregnancy

looks like red-polyp on skkin - frequently ulcerates and bleeds and tend to be on lips an gums

37
Q

what is a glomus tumor?

A

benign painful tumor under the fingernails

38
Q

what is bacillary angiomatosis? what is it associated with?

A

benign but can be mistaken for karposi sarcoma because looks like multiple raised puplish spots

caused by bartonella henselae - cat scratch disease in immunocompromised

39
Q

what vascular tumor is associated with prior radiation therapy?

A

angiosarcoma - often face, scalp, neck or breast

40
Q

what is a potential consequence of perisisten lymphadema?

A

lymphangiosarcoma

41
Q

vasculitis associated with weak pulses in upper extrmeities

A

takiyatsu

42
Q

vasculitis associated with necrotizing granulomas of lung and necrotizing glomerulonephritis

A

granulomatosis with polyangitis

43
Q

vasculitis associated with necrotizing immune complex inflammation of viseral/renal vessels

A 
polyarteritis nodosa
(spares lungs, -ANCA)
44
Q

vasculitis associated with young male smokers

A

buerger ddisease

45
Q

vasculitis associated with young asian women

A

takayasu disease

46
Q

vasculitis associated with young asthmatics

A

churg-strauss

47
Q

vasculitis associated with infants and young children; involves coronary arteries

A

kawasaki

48
Q

most common vasculitis

A

temporal arterisit

49
Q

vasculitis associated with hep B

A

polyarteritis nodosa

50
Q

vasculitis associated with occlusion of opthalamic artery that can lead to blindness

A

temporal arteritis

51
Q

vasculitis associated with perforation of the nasal septum

A

wegners

52
Q

vasculitis associated with unilateral headache with jaw claudication

A

temporal arteritis

53
Q

benign, raised, red lesion about the size of a mole in older patients

A

cherry hemangioma

54
Q

raised, red area present at birth increases in size initially then regresses over months to years

A

strawberry angioma

55
Q

lesion caused by lymphoangiogenic growth factors in HIV patient

A

karposi-sarcoma

56
Q

polypoid red lesion found in prgnancy or after trauma

A

pyogenic angioma

57
Q

benign, painful red-blue tumor under fingernailos

A

glomus tumor

58
Q

cavernous lymphangioma associated with turner syndromwe

A

cystic hygroma

59
Q

skin papule in AIDS patients caused by bartonella

A

bacilliary angiomatosis

60
Q

what is the treatment for bueger disease?

A

smoking cessation

61
Q

what is the trwatment for temporal arteritis

A

high dose steroids

STEP 1 (77 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions