Anti-coagulation

Question 1

Glanzmann thrombasthenia is an autosomal recessive disorder caused by ______.

Answer 1

defective GPIIb/IIIa on platelets

Question 2

What drug inhibits thromboxaine A2 (TXA2)? What function is inhibited?

Answer 2

Aprin

aggregation (takes place after adhesion upon release of ADP etc)

Question 3

What is the MOA for abciximab?

Answer 3

GPIIb/IIIa receptor antagonist - inhibits binding to fibrinogen and thus inhibits platelet aggregation

Question 4

what is the MOA for argatroban?

Answer 4

direct thrombin inhibitor - used to treat heparin-induced thrombocytopenia

Question 5

what is the MAO of dabigatran?

Answer 5

direct ORAL thrombin inhibitor - used in atrial fibrullation/enousthromboembolism

Question 6

what is the MAO of heparin?

Answer 6

potentiates antithrombin III activity, leading to inactivation of thrombin and factor Xa

Question 7

what is the MAO of warfarin?

Answer 7

prevents vitamin-K mediated carboxylation of several coagulation factors

Question 8

what is the MAO of bivalirudin?

Answer 8

direct thrombin (factor IIa) inhibitor prevents conversion of fibrinogen to fibrin