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STEP 1 > leukemias, lymphomas and lymphoproliferative disorders > Flashcards

leukemias, lymphomas and lymphoproliferative disorders Flashcards

1
Q

what is mylodysplastic syndrome?

A

primarily effects men and occus with median age ~65

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2
Q

what type of leukemia is offten associated with DIC

A

acute promyelocytic leukemia with auer rods - release of auer rods is prothrombotic

DIC has long PT and PTT

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3
Q

what is the translocation for APL?

A

t(15;17)

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4
Q

what is a aur rod made of?

A

cyrstalized myeloperoxidase

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5
Q

what leukemia is most commonly seen in older adults (5th-6th decade)

A

AML

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6
Q

what is the consequence of t(15;17)?

A

results in a disruption of retinoic acid receptor (RAR) required for myeloblast maturation

ATRA is treatment for APL because it induces maturation of neoplastic cells

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7
Q

7 yr old Down syndrome pt has leukemia. What is it?

A

ALL

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8
Q

3 yr old downsyndrome pt has leukemia. What is it?

A

Acute megakaryoblastic leukemia

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9
Q

pt has leukemic infiltration of the gums. What caused this?

A

acute monocytic leukemia

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10
Q

child presents with lytic bone lesions and skin rash with recurrent otitis media and a mass invovling the mastoid bone. Cells are immaure and are innefective at stimulating T-cells via antigen presentation. S100 and CD1a +. What is the diagnosis?

A

Langerhans cell histiocytosis

proliferative dissorder of dendritic (langerhans) cells

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11
Q

leukemia in 0-14yrs of age?

A

ALL

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12
Q

15-39

A

AML

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13
Q

40-59

A

AML + CML

CML has >30% blasts

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14
Q

> 60

A

chronic lymphocytic leukemia

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15
Q

5 yr old with lymphoblasts that are CD10 positive and positive to TdT.

A

acute lymphoblastic leukemia/lymphoma

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16
Q

what markers are seen the the most common adult leukemia?

A

CD20+, CD5+, smudge cells and small mature appearing lymphocytes

chronic lymphocytic leukemia

17
Q

what hematologic condition is associated with CLL?

A

autoimmune hemolytic anemia

18
Q

pt was found to have a t(11;14), what is the likely disease?

A

mantle cell lymphoma

19
Q

what causes mantal cell lymphoma?

A

Cyclin D1 activation

20
Q

pt is found to have a t(8;14) translocation - what is the likely disorder?

A

burkett lymphoma

21
Q

what cuases burkett lymphoma?

A

c-myc gain of function activation of proto-onco gene

22
Q

pt has dry tap on marrow aspiration with massive spelomegally and no lymphadenopathy. Cells stain for tattrate-resistant acid phosphatase. What is the disorder?

A

Hairy Cell leukemia

adult males

mature B cell tumor

23
Q

adult pt presents with rash, hepatosplenomegally, generalized lymphadenopathy and lytic bones lesions with hypercalcemia. what do they have?

A

Adult T cell leukemia lymphoma

association with HTLV-1

most common in Japan and carribiean

WITHOUT RASH THIS WOULD DESCRIBE MULTIPLE MYELOMA

STEP 1 (77 decks)

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