random pharmacology Flashcards
what is eflornithine? MOA, used for?
ornithine decarboxylase inhibitor - interrupts DNA stabilization and rapair - leads to decreased cell growth and increased apoptosis
-used to decrease rapidly growing hair
what is dantrolene? MOA, used for?
ryanodine receptor blocker - prevents calcium release from sarcoplasmic reticulum and functions as a post-synaptic muscle relaxant.
what is metoclopromide? MOA, used for, side effects?
dopamine receptor antagonist used for nausea or vomiting or potentially GERD
MAJOR RISK FOR NEUROLEPTIC MALIGNANT SYNDROME
treat with bromocriptine or amantidine
what is pramipexole? MOA, used for?
dopamine agonist used for restless leg syndrome
what is ropinirole? MOA, used for?
dopamine agonist used for restless leg syndrome
what is akathisia? what can cause it?
restless urge to move appendages
consequence of antidopaminergic antipsychotics
what is the treatment for antidopaminergic antipsychotic induced-akathisia?
beta-blockers e.g. propranolol
what is used for treatment of cataplexy (sudden loss of muscle tone associated with narcolepsy)?
muscarinic antagonists - e.g. atropine
what drug antagonises affect of ADH on priciple cells in the collecting duct resulting in nephrogenic diabedes insipidus?
lithium
procainamide
hydralazine
isoniazid
all can cause what condition?
what is the shared property of these drugs that’s implicated?
drug-induced lupis with anti-histone antibody positivity
all metabolized by phase II acetylation in the liver via N-acetyltransferase
slow acetylators are at greatest risk for developing acute DILE and specifically peripheral neuropathy from isoniazid
what’s the equation for half life?
t1/2= 0.7 x Vd / clearance
what’s the formula for clearance?
clearance = 0.7 x Vd / t1/2
what is acitretin?
synthetic retinoid used topically for psoriasis - don’t mix with alcohol, forms 120 day metabolite that’s highly teratogenic
what is sulfasalazine?
disease modifiying anti-rheumatic drug used in psoriatic arthritis
causes jaundice in breast fed infants
what is calcipotriol?
vitamin D analogue used in psoriases (topically)
