Heavy metals, hemochromatosis, wilsons

Question 1

A 23 yr old with corneal changes visible to the naked eye is most likely to develop what associated condition?

Answer 1

basal ganglia atrophy

Wilson’s disease -system

Question 2

what is wilson’s disease?

Answer 2

autosomal resessive condition assicated with mutations that decrease the formation and secretion of ceruplasmin, thus decreasing hepatic copper secretion into the billiary system.

Question 3

what are keyser fleisher rings?

Answer 3

feature of wilson’s disease

caused by copper deposition within the descemet’s membrane in the cornea

precursor to basal ganglia atrophy

Question 4

what metal deposition disorder is associated with the development of diabetes mellitus?

Answer 4

hemochromatosis

Question 5

What occupation is associated with lead poisoning in adults?

Answer 5

manufacturing of batteries or ammunition

Question 6

what does the anemia of lead poisoning present as?

Answer 6

microcitic with basophilic stippling (inclusions of aggregated ribosomes) and ringed sideroblasts (iron loaded mitochondria that stain with prussian blue)