oncogenes

Question 1

BCR:ABL
BCL-2
CCND1
C-Myc
L-Myc
N-MYC
ERB-B2
CDK4
RET
C-KIT
RAS

Answer 1

CML - 9;22 translocation
Follicular lymphomas - 14;18 translocation
Mantle cell lymphomas - 11;14 translocation
Burkitt’s lymphoma - 8;14 translocation
Lung tumor amplification
Neuroblastoma amplification
Breast, ovarian, and gastric carcinomas amplification
Melanoma amplification
Multiple endocrine neoplasia IIA and B point mutation
Gastrointestinal stromal tumor (GIST) point mutation
Colon carcinoma point mutation

Question 2

CML
Follicular and undifferentiated lymphomas
Mantle cell lymphomas
Burkitt's lymphoma
Lung tumor
Neuroblastoma
Breast, ovarian, and gastric carcinomas
Melanoma
Multiple endocrine neoplasia IIA and B
Gastrointestinal stromal tumor (GIST)
Colon carcinoma

Answer 2

BCR:ABL	9;22 translocation 
BCL-2	14;18 translocation
CCND1	11;14 translocation
C-Myc	8;14 translocation
L-Myc	amplification
N-MYC	amplification
ERB-B2	amplification
CDK4	amplification
RET	point mutation
C-KIT	point mutation
RAS	point mutation

Question 3

CML

Answer 3

BCR:ABL 9;22 translocation

Question 4

Follicular and undifferentiated lymphomas

Answer 4

BCL-2 14;18 translocation

Question 5

Mantle cell lymphomas

Answer 5

CCND1 11;14 translocation

Question 6

Burkitt’s lymphoma

Answer 6

C-Myc 8;14 translocation

Question 7

Lung tumor

Answer 7

L-Myc amplification

Question 8

Neuroblastoma

Answer 8

N-MYC amplification

Question 9

Breast, ovarian, and gastric carcinomas

Answer 9

ERB-B2 amplification

Question 10

Melanoma

Answer 10

CDK4 amplification

Question 11

Multiple endocrine neoplasia IIA and B

Answer 11

RET point mutation

Question 12

Gastrointestinal stromal tumor (GIST)

Answer 12

C-KIT point mutation

Question 13

Colon carcinoma

Answer 13

RAS point mutation

Question 14

what is the function of ras

Answer 14

signal transducer

Question 15

what is the function in neoplasia of HER2/neu

Answer 15

growth factor receptor upregulation