lung cancer

Question 1

what is a marker for lung adenocarcinoma?

Answer 1

CEA

Question 2

mutation in k-ras oncogene can lead to what type of lung cancer

Answer 2

adenocarcinoma

Question 3

where is adenocarcenoma of lung found?

Answer 3

periphery of lung

Question 4

where is large cell carcenoma of the lung found

Answer 4

periphery

Question 5

what features define large cell carcinoma

Answer 5

anaplastic undifferentiated cells with giant cells of variouos pleomorphisms

Question 6

does large cell carcinoma of lung respond to chemo?

Answer 6

no - very poor prognosis

Question 7

what type of lung cancer presents in the center of lung as a hilar mass or cavitated lesion on x-ray or chest CT that also shows keratin pearls on histology?

Answer 7

squamous cell lung carcinoma

Question 8

which type of lung cancer is likely to secrete PTHrP?

Answer 8

squamous cell carcinoma

finding is high calcium with low PTH

Question 9

what featues differentiatee squamous cell from small cell carcinoma?

Answer 9

both are centrally located

small cell has very small nucleus to cytoplasm ratio

small cell is morelykely to secrete ATCH and ADH

small cell can have cells which produce auto-antibodies against calcium channels (lamert-eaton)

Question 10

what is a potential complication of bronchogenic carcinoma?

Answer 10

superior vena cava syndrome - obstruction of superior venacava by pancoast tumor (aka superior sulcus tumour; aka when a tumor from a primary bonchogenic carcinoma arises in the lung apex and invades the surrounding soft tissues.)