anti-arrythmics Flashcards
What is the only drug that slows heart rate but does not affect contractility?
ivabradine - slows SA node firing by selectively inhibiting sunny sodium - slowing and prolonging phase 4 depolarization
what effect do verapamil and diltiazem have on myocardial action potentials?
type 4 calcium channel blockers - inhibit L-type calcium channels during phase 2 depolarization which prolongs the AP.
slows sinus rate
prolong conduction through AV node
decrease contractility
what effect do class 1A antiarrythmics have on myocardial action potential?
How does this profile contrast
Class 1A anti-arrythmics (disopyramide, qunidine, procainamide) decrease the slope of phase 0 depolarization, and slow conduction
Specific features of Class1A
1) INCREASED ACTION POTENTIAL DURATION
2) increased effective refractory period in ventricular action potential
3) prolonged QT interval (prolonged phase III repolarization)
(Class 1A drugs also depress contractility)
By contrast, class 1B (lidocaine and mexiletine) cause: 1)DECREASED ACTION POTENTIAL DURATION and preferentially affect ischemic or depolarized perkinje or ventricular tissue making them particularly suitable for threatment of post-MI arrhythmias (DOC=lidocaine)
What are the class IC antiarrythmics? What effect do they have on APs?
Flecainide and prpafenone
specifically prolong the effective refractory period in the AV node and accessory bipass tracts but have no effect on action potential duration in kurkinje and ventriuclar tissue?
What effect do potassium channel blockers have on cardiac action potentials?
class III anti-arrythmics act on phase 3 slow delayed rectifier potassium channels
They delay and prolong repolarization
prolong AP duration
prolong refractory period
NOT USED FOR CHF!
what class of antiarrythmic is used for atrial and ventricular arrythmias particularly re-entrant and ectopic SVT and VT
Class 1A - atrial and ventricular arrythmias particularly re-entrant and ectopic SVT and VT
what class of antiarrythmic is used for acute ventricular arrhythmia especially post-MI
Class 1B - used for acute ventricular arrhythmia especially post-MI because specifically affects ischemic tissue
what class of antiarrythmic is used for atrial fibrillation (and only as last resort used for VT)
Class 1C - atrial fibrillation (and only as last resort for VT)
specifically prolong the effective refractory period in the AV node and accessory bipass tracts but have no effect on action potential duration in kurkinje and ventriuclar tissue?
what class of antiarrythmic is used for afib, aflutter, VT and produce a significantly prolonged AP with increased effective refractory perior and prolong QT interval?
Class III - afib, aflutter, VT (amiodorone or sotalolol only)
what are class 1A used for? Why?
atrial and ventricular arrythmias particularly re-entrant and ectopic SVT and VT
because prolonged ventriuclar AP (and also some effect of prolonged phase 3 repolaization) slows the rate of ventricular contraction in setting of tachy independently from pacemaker activity
what drugs should not be used in a patient with CHF?
flecainide and propafenone - contraindicated with CHF
pt receives a medication and later reports corneal deposits and blue/grey deposits on their skin. what was the drug?
amiodarone
what are the main side effects of amiodarone?
pulmonary fibrosis
hepatotoxicity
hyperthyroidism/hypothyroidism (40% iodine by weight)
bradycardia, heart block, heart failure
Pt is treated for tachycardia and later develops dislipidemia. what was the drug?
metropolol
what is the treatment for betablocker overdose?
saline, atropine and glucagon