Tumor markers Flashcards
1
Q
PSA (Prostate-specific antigen)
A
Normal Function = Liquefaction of semen
Prostate carcinoma
also released with BPH and prostatitis
increase in bound PSA (as compared to free PSA) is suggestive of cancer
2
Q
Prostatic acid phosphatase
A
Prostate carcinoma
3
Q
α-fetoprotein (AFP)
A
Normal Function = fetal albumin
Hepatocellular carcinomas
Nonseminomatous germ cell tumors of the testis
e.g. yolk sac tumor
4
Q
β-hCG
A
Hydatidiform moles
Choriocarcinomas
Gestational trophoblastic tumors
5
Q
CA-125
A
Released by peritoneum with irritation (can be elevated in endometriosis)
Ovarian cancer Epithelial tumors
6
Q
TRAP (Tartrate-resistant acid phosphatase)
A
Hairy cell leukemia
7
Q
CA-19-9
A
Pancreatic adenocarcinoma
8
Q
S-100
A
Melanoma
Neural tumors
Astrocytomas
9
Q
Alkaline phosphatase
A
Marker of bone formation
osteoblastic metastases to bone (e.g. prostate)
Paget’s disease of bone
Also released when bile ducts are damaged
obstructive biliary disease
10
Q
Bombesin
A
Neuroblastoma
Lung cancer
Gastric cancer
