Unit 3- Muscarinic Antagonists

Question 1

Muscarinic Antagonists

Answer 1

Block Ach from binding and activating muscarinic receptors, nonspecific, difficult to achieve selective action

Question 2

Atropine

Answer 2

Muscarinic blocking agent, treats bradyarrhythmia, dilates pupil, treat anti-cholinesterase toxicity

Question 3

Muscarinic Antagonist Effects

Answer 3

Increase HR and cardiac output, relax GI, dilate bronchioles, pupil dilation, urine retention, minimal CNS effects

Question 4

Use of Muscarinic Antagonists

Answer 4

Antispasmodics, reduce GI hypermobility, decrease hypertonicity of uterus, bladder, ureter, bile duct, and bronchiles

Question 5

Muscarinic Antagonist Adverse Effects

Answer 5

Excess salivation, vomiting, increased IOP

Question 6

Glycopyrrolate

Answer 6

Antimuscarinic, lower chance tachyarrhythmia, decreases gastric secretion, reduces intestinal motility, reduces excessive secretion

Question 7

N-butylscopolamine bromide

Answer 7

Antimuscarinic, treats colic, fewer systemic side effects, airway obstruction in horse

Question 8

Propantheline

Answer 8

Used in dogs with myasthenia gravis that have muscarinic side effects, antisecretory agent to treat diarrhea, relax rectum in horse