Unit 3- Adrenergic Antagonists

Question 1

Prazosin Selectivity

Answer 1

α1

Question 2

Phenoxybenzamine Selectivity

Answer 2

α1

Question 3

Phentolamine Selectivity

Answer 3

α

Question 4

Antipemezole Selectivity

Answer 4

α2

Question 5

Yohimbine Selectivity

Answer 5

α2

Question 6

Carvedilol Selectivity

Answer 6

β>α1

Question 7

Propanolol Selectivity

Answer 7

β

Question 8

Timolol Selectivity

Answer 8

β

Question 9

Metoprolol Selectivity

Answer 9

β1

Question 10

α Antagonist Structure

Answer 10

Diverse, competitive antagonists

Question 11

Phenothiazine Tranquilizers

Answer 11

α antagonists blocking receptors, causing decrease in peripheral vascular resistance

Question 12

α Antagonist Cardiovascular

Answer 12

Dilate vessels

Question 13

EPI Reversal Effect

Answer 13

Pretreating with α1 antagonists to reduce peripheral vascular resistance due to EPI

Question 14

α1 Antagonist Effects

Answer 14

Decrease resistance to urine flow

Question 15

α2 Antagonist Effects

Answer 15

Antiplatelet aggregation, stimulate insulin, reverse sedation

Question 16

α Antagonist Effects

Answer 16

3rd eyelid protrusion, miosis, nasal stuffiness

Question 17

Nonselective α Antagonists

Answer 17

Phenoxybenzamine, phenothiazine tranquilizers, and trazodone

Question 18

Phenoxybenzamine

Answer 18

Irreversibly blocks α receptor to inhibit NE reuptake, antagonizes histamine, Ach, and serotonin receptors, manages catecholamine excess

Question 19

Selective α1 Antagonists

Answer 19

Prazosin, tamsulosin, silodosin

Question 20

Prazosin

Answer 20

Vessel dilation, decrease urine flow, reduces urethral pressure, decreases MAP

Question 21

Tamulosin

Answer 21

Higher affinity for urethra and prostate than vascular smooth muscle, decreases intraurethral pressure

Question 22

Silodosin

Answer 22

Decreases intraurethral pressure

Question 23

Selective α2 Antagonists

Answer 23

Reverse sedative effects of α2 agonists; yohimbine, tolazoline, atipamezole

Question 24

Yohimbine

Answer 24

Increases NE release to cause stimulation, HR increase, and BP increase, increases GI motility, antagonizes serotonin receptors

Question 25

Tolazoline

Answer 25

α antagonist to reverse xylazine and other α2 agonists in horses

Question 26

Atipamezole

Answer 26

Reverses α2 agonist sedation, effective in all species, mostly used in small animal

Question 27

α Agonist Sedatives

Answer 27

Block presynaptic α receptors, suppressing NE release via negative feedback

Question 28

β Antagonist Cardiovascular Effects

Answer 28

Decreases cardiac output, can lower BP

Question 29

β Antagonist Pulmonary Effects

Answer 29

Bronchoconstriction and increased airway resistance

Question 30

β Antagonist Ophthalmic Effects

Answer 30

Reduce intraocular pressure by decreasing aqueous humor production

Question 31

β Antagonist Metabolic Effects

Answer 31

Inhibit lipolysis and glycogenolysis, delay recovery from hyperglycemia

Question 32

First Gen β Antagonists

Answer 32

Nonselective, propanolol

Question 33

Second Gen β Antagonists

Answer 33

β1 selective, metoprolol, atenolol, esmolol

Question 34

Third Gen β Antagonists

Answer 34

Nonselective with additional cardiovascular effects, carvedilol

Question 35

Propanolol

Answer 35

Competitive antagonist blocking receptors, decreases HR and cardiac output, decreases oxygen demand, increases airway resistance

Question 36

Propanolol Uses

Answer 36

Treats tachyarrhythmia, hypertension, cardiomyopathy, and thyrotoxicosis

Question 37

Propanolol Side Effects

Answer 37

Upregulation of β receptors, excess β stimulation with abrupt stop of treatment, bronchospasm

Question 38

Metoprolol

Answer 38

Blocks β2 receptors, decreases HR and cardiac output, decreases oxygen demand, reduces BP, inhibits agonist induced tachycardia

Question 39

Metoprolol Uses

Answer 39

Tachyarrhythmia, premature contraction, hypertension, hypertrophic cardiomyopathy, thyrotoxicosis, safe in asthmatics

Question 40

Atenolol

Answer 40

Decreases HR and cardiac output, decreases MAP

Question 41

Atenolol Uses

Answer 41

Arrhythmia, hypertension, hypertrophic cardiomyopathy

Question 42

Atenolol Side Effects

Answer 42

Can block β2 receptors, not for asthmatics, reduces cardiac output, lethargy, hypotension, diarrhea

Question 43

Esmolol

Answer 43

Ultra short acting

Question 44

Esmolol Uses

Answer 44

Tachyarrhythmia, ventricular outflow obstruction

Question 45

Esmolol Side Effects

Answer 45

Significant cardiac output reduction

Question 46

Carvedilol

Answer 46

β blocker, some α1 antagonism, vasodilator, free radical scavenger

Question 47

Carvedilol Uses

Answer 47

Anti arrhythmic, dilated cardiomyopathy and chronic valve disease

Question 48

Chronic Mitral Valvular Disease

Answer 48

Most common cause of heart disease and CHF in dogs, treated with carvedilol

Question 49

Hypertrophic Cardiomyopathy

Answer 49

Most common heart disease in cats, treated with atenolol

Question 50

Subaortic Stenosis

Answer 50

Congenital cardiac abnormality in dogs, treated with atenolol