Unit 3- Dermatopharmacology Flashcards
Topical Absorption
Between stratum corneum cells, through hair follicles, through sweat or sebaceous glands
Skin Permeability
Drugs must be lipophilic, heavily haired animals have better absorption
Vehicle
Substance with the active agent to be administered
Antiseborrheics
Keratolytics and keratoplastics
Keratolytics
Hydrate and soften stratum corneum to promote mechanical removal
Keratoplastics
Normalize keratinization by slowing basal cell proliferation
Salicylic Acid
Keratolytic and keratoplastic, antimicrobial and antipruritic
Sulfur
Keratolytic and keratoplastic, follicular flushing action, antibacterial, antipruritic
Coal Tar
Keratolytic and keratoplastic, degreasing, not safe for felines
Benzoyl Peroxide
Keratolytic, degreasing, follicular flushing, bactericidal, oxidizer
Resorcinol
Keratolytic, antimicrobial, hydrates keratin
Selenium Sulfide
Keratolytic and keratoplastic, slows cell proliferation, can irritate mucous membrane
Itching Sensation Substitution
Menthol, camphor, warm soak, ice bath
Skin Protection
Protect from scratching, biting, irritant, humidity, temp
Anesthetize Peripheral Nerves
Local anesthetics, can cause allergic sensitization
Glucocorticoids
Topical or oral use for pruritus
Escharotics
Precipitate proteins to form a crust and then scar
Irritants
Mask pain by milder pain, induce healing action
Candida Treatment
Amphotericin B, Clotrimazole, Miconazole
Malassezia Treatment
Chlorohex and ketoconazole, Clotrimazole, Miconazole, Thiabendazole
Dermatophyte Treatment
Clotrimazole, Miconazole, Nystatin, Sulfur, Thiabendazole
Transdermals Hazardous to Humans
DMSO, anticancer, nitroglycerine, antiparasitics
Nitroglicerin
Relaxes vascular smooth muscle, treats cardiogenic edema
Fentanyl
Narcotic
