u3 - aos1 dp5

Question 1

parkinson’s disease

Answer 1

CNS neurodegenerative disease
characterised by motor and non- motor symptoms
degeneration of nervous system
develop slowly

Question 2

motor symptoms

Answer 2

used for diagnosis
- tremors
- muscle rigidity (stiffness)
- slowness of voluntary movement (bradykinesia)
- posture, balance, walking problems

Question 3

non - motor symptoms

Answer 3

• decreased sense of smell
• sweating/ sensitivity to temp
• fatigue
• mental health problems (confusion, panic, anxiety, depression)
• cognitive function problems (slow thinking, impaired planning, decision making, memory loss)

Question 4

substantia nigra

Answer 4

midbrain
role in the control of voluntary uscle movement to execute smooth and coordinated manner
motor symptoms are due to degeneration of neurons in substantia nigra
neurons in SN produce dopamine

Question 5

dopamine

Answer 5

neurotransmitter
excretory (mainly) and inhibitory
role in movement, learning, emotional experience, focus, motivation, arousal

Question 6

dopamine and substantia nigra

Answer 6

if fewer neurons in SN, less dopamine will be produced

Question 7

treatment of parkinson’s

Answer 7

no cure
medication can relieve motor symptoms
levodopa - converted into dopamine by neurons
dopamine agonists - mimic role of dopamine