TXA (Tranexamic Acid)

Question 1

Pharmacology and presentation of Tranexamic Acid?

Answer 1

1g:10ml

Antifibrinolytic medicine. It blocks the conversion of plasminogen to plasmin, reducing fibrinolysis (breakdown of blood clots) and bleeding.

Question 2

Indicators of Tranexamic Acid?

Answer 2

• Recent (<3 hours) traumatic injuries and COAST score 3 or >
• Post-Partum Haemorrhage.

Question 3

Contraindications of Tranexamic Acid?

Answer 3

• Known allergy
• Do not administer in same line as blood products

Question 4

Cautions of Tranexamic Acid?

Answer 4

• NIL

Question 5

Side Effects of Tranexamic Acid?

• SHN

Answer 5

• Headache
• Nausea and/or vomiting
• Seizures.

Question 6

Dosing Regimes of Tranexamic Acid?

Answer 6

Traumatic Injuries with a COAST Score ≥ 3; or PPH
- Via Clinical Consult Only – ICP-DAT / CMO

Question 7

Onset and duration of Tranexamic Acid?

Answer 7

• Onset = 1–3 minutes
• Duration = 7–8 hours