Dexamethasone

Question 1

Pharmacology and presentation of Dexamethasone?

Answer 1

8mg/2ml Vial

Dexamethasone, a corticosteroid (glucocorticoid), mimics steroids normally secreted by the adrenal cortex. Its properties allow for inhibition of inflammatory reactions and immunosuppression. It is often also used for chemotherapy associated nausea and a number of palliative symptoms’ control.

Question 2

Indicators of Dexamethasone?

Answer 2

• Bronchospasm associated with acute resp distress nonresponsive to nebulised salbutamol
• Acute exacerbation of COPD
• Suspected Croupe
• Severe Covid

Question 3

Contraindications of Dexamethasone?

Answer 3

• Known allergy.

Question 4

Cautions of Dexamethasone?

Answer 4

• If solution is not clear or is contaminated it should be discarded (as no antimicrobial agent).

Question 5

Side Effects of Dexamethasone?

Answer 5

• NIL

Question 6

Dosing Regimes of Dexamethasone?

Answer 6

Croup
- Not indicated for adults
- Paed = 60mcg/kg PO, single dose to a max of 12mg

Question 7

Onset and duration of Dexamethasone?

Answer 7

• Onset = 30–60 minutes
• Duration = 72 hours