Dexamethasone

Question 1

Pharmacology and presentation of Dexamethasone?

Answer 1

8mg/2ml Vial

Dexamethasone, a corticosteroid, more specifically a glucocorticoid, mimics steroids normally secreted by the adrenal cortex. Its properties allow for inhibition of inflammatory reactions, vasocontractile actions and suppressing the immune system. It is often also used for chemotherapy associated nausea and a number of palliative symptoms’ control.

Question 2

Indicators of Dexamethasone?

Answer 2

• Croup
• Valid chemotherapy or palliative care plan authorising its use

Question 3

Contraindications of Dexamethasone?

Answer 3

• Known allergy.

Question 4

Cautions of Dexamethasone?

Answer 4

• If solution is not clear or is contaminated it should be discarded (as no antimcrobial agent).

Question 5

Side Effects of Dexamethasone?

Answer 5

• NIL

Question 6

Dosing Regimes of Dexamethasone?

Answer 6

Croup
- Not indicated for adults
- Paed = 60mcg/kg PO, single dose to a max of 12mg

Question 7

Onset and duration of Dexamethasone?

Answer 7

• Onset = 30–60 minutes
• Duration = 72 hours