Magnesium Sulphate

Question 1

Pharmacology and presentation of Magnesium Sulphate?

Answer 1

10mmoL (2.47g)/5ml Ampoule

Magnesium is an electrolyte that has an important cofactor in multiple processes, including causing vasodilation and bronchodilation through inhibition of smooth muscle contraction. Magnesium ions also possess anticonvulsant and anti-arrhythmic properties.

Question 2

Indicators of Magnesium Sulphate?

• TEAM

Answer 2

• Severe life-threatening asthma
• Torsades de Pointes VT
• Marine Envenomation (Box Jellyfish and Irukandji Syndrome)
• Eclampsia.

Question 3

Contraindications of Magnesium Sulphate?
- A RAv

Answer 3

• Known allergy
• Atrioventricular block
• Renal failure.

Question 4

Cautions of Magnesium Sulphate?

Answer 4

• Renal impairment.

Question 5

Side Effects of Magnesium Sulphate?
- Pain Mag (3 downs and a loss)

Answer 5

• Pain at cannula site
• Magnesium toxicity (hypotension, respiratory depression, loss of
  deep tendon reflexes, coma).

Question 6

Dosing Regimes of Magnesium Sulphate?

Answer 6

Torsades de Poiintes VT
- 10mmOL IV/IO, repeating once at 10mins via infusion to a max of 20mmOL
- For 10 minute administration mix 10mmoL with NaCl 0.9% up to a total of 10ml and run the driver at 60ml/hr.

Question 7

Onset and duration of Magnesium Sulphate?

Answer 7

• Onset = 1 minute
• Duration = 30 minutes