Ceftriaxone

Question 1

Pharmacology and presentation of Ceftriaxone?

Answer 1

2g powder ampoule

Ceftriaxone is a broad-spectrum cephalosporin antibiotic. That inhibits production of the bacteria cell wall, causing bacteria death.

Question 2

Indicators of Ceftriaxone?

Answer 2

• Suspected meningococcal septicaemia, or meningitis

Question 3

Contraindications of Ceftriaxone?

-1PAC

Answer 3

• <1 month of age
• Do not co-administer with Ca containing fluids including Hartmanns
• Known allergy
• Anaphylaxis to Penicillin-based drugs.

Question 4

Cautions of Ceftriaxone?

Answer 4

• Mild allergy to Penicillin-based drugs

Question 5

Side Effects of Ceftriaxone?

Answer 5

• Skin rash
• Nausea/vomiting
• Pain at IM injection site

Question 6

Dosing Regimes of Ceftriaxone?

Answer 6

• Reconstitute with 7mls of lignocaine to achieve 2g in 8ml, administer in 2 sites (preferably upper outer thigh) with max 4mls per site.
• Adults = 2g IM single dose
• Paeds >10years = 2g IM, single dose
• Paeds >1month = 50mg/kg IM to a max of 2g, single dose

Question 7

Onset and duration of Ceftriaxone?

Answer 7

• Onset = 60secs IM
• Duration = 1day