Naloxone

Question 1

Pharmacology and presentation of Naloxone?

Answer 1

0.4mg:1ml

Opiate receptor antagonist that reverses the effects of opiates, particularly respiratory depression and sedation

Question 2

Indicators of Naloxone?

Answer 2

• Respiratory depression secondary to narcotics.

Question 3

Contraindications of Naloxone?

Answer 3

• Known allergy.
• Newborn.

Question 4

Cautions of Naloxone?
- DP Boob

Answer 4

• Patients with pre-existing cardiac disease
• Breastfed infants of opioid-dependent mothers
• Patients with known dependence, be prepared for agitation and possible combativeness. Adequately oxygenate pt prior

Question 5

Side Effects of Naloxone?
- PC Withdraw

Answer 5

• Narcotic withdrawal: combative, vomiting, nausea, sweating, tachycardia and hypertension
• Convulsions
• Pulmonary oedema.

Question 6

Dosing Regimes of Naloxone?

Answer 6

IM
- Adults = 1.6-2mg IM, repeating 10minutely as required to a max of 4mg
- Paeds = 0.1mg/kg IM, single dose only with a maximum total of 2mg

IV
- Adults = 0.1mg IV, repeating 2 minutely until pt self-ventilating to a max of 2mg IV

Question 7

Onset and duration of Naloxone?

Answer 7

• Onset = 1–5 minutes
• Duration = 60 minutes