Aspirin

Question 1

Pharmacology and presentation of Aspirin?

Answer 1

300mg tablets.

An anti-platelet aggregator with analgesic, antipyretic and anti-inflammatory effects. Inhibits cyclooxygenase reducing the formation of prostaglandins and thromboxane.

Question 2

Indicators of Aspirin?

Answer 2

• Acute Coronary Syndrome including ACPO.

Question 3

Contraindications of Aspirin?

• 3x blood, 2x drugs, 1x person

Answer 3

• Known allergy or hypersensitivity to NSAIDs
• Chest pain associated with psychostimulant overdose with SBP>160mmHg
• Bleeding or clotting disorders
• Suspected aortic aneurysm
• Active and current gastrointestinal bleeding or ulcers
• Patient <18 years of age.

Question 4

Cautions of Aspirin?

-PAPA

Answer 4

• History of peptic ulcers
• Asthma
• Patients on other anticoagulant medications
• Pregnancy.

Question 5

Side Effects of Aspirin?
- Begin HG

Answer 5

• Epigastric discomfort or pain
• Gastritis
• Gastrointestinal bleeding
• Nausea and/or vomiting
• Bronchospasm (rare)
• Increased bleeding times
• Hypersensitivity reaction.

Question 6

Dosing Regimes of Aspirin?

Answer 6

ACS
- 300mg PO once, not required if evidence of 300mg+ aspirin dose in the last 12hrs

Question 7

Onset and duration of Aspirin?

Answer 7

• Onset = ~10 minutes
• Duration = ~7 days