Transmissible Encephalopathies Flashcards
1
Q
1) Transmissible encephalopathies can be diagnosed by detecting infective prions in the brain.
A
true
2
Q
2) In the case of transmissible encephalopathies lesions can only be seen in the central nervous system
A
true?
3
Q
3) Prion diseases can be diagnosed by detecting the antibodies with ELISA
A
false, not Ab but Prion Protein threats
4
Q
4) There are major differences in the amino acid sequence of the normal and infective prions
A
false
5
Q
5) Spongiform encephalopathies of animals occur worldwide except Australia and New Zealand
A
true
6
Q
6) Prions can become infective prions as a result of a mutation
A
true
7
Q
7) In the case of transmissible encephalopathies always degenerative lesions can be seen
A
true
8
Q
8) In the case of transmissible encephalopathies meningoencephalitis is a typical postmortem lesion
A
false
9
Q
9) Infective prions are resistant against the usual concentration of disinfectants
A
true
10
Q
10) Agents of transmissible encephalopathies are most frequently detected with PCR
A
false
11
Q
11) Weight loss is a clinical sign of Transmissible encephalopathies
A
true
12
Q
12) ELISA can be used for the detection of infective prions in the brain
A
true
13
Q
13) The folding of normal and the infective prion is different
A
true
14
Q
14) Infective prions are resistant against proteases
A
true
15
Q
15) Infective prions can survive 100 °C.
A
true
16
Q
16) Prions consist of protein and DNA
A
false
17
Q
17) Chronic prion has no nucleic acid inside
A
true
18
Q
18) Chronic prion is inactivated by boiling
A
false
19
Q
19) Chronic prion form has other form than normal prions
A
true
20
Q
20) Prions contain protein and DNA
A
false
21
Q
21) Infection with infective prions generally happens per os
A
false, should be true
22
Q
22) Transmissible encephalopathies are slow diseases
A
true
23
Q
23) In the case of transmissible encephalopathies encephalitis can be seen in the grey material of the brain
A
false
24
Q
24) Transmissible encephalopathies are caused by prions
A
true
25
25) PCR is used to the detection of prions
false
26
26) Prions always cause viraemia in the infected hosts
false
27
27) Prions are spreading in the host along the nerves
true
28
28) Normal prions are essential components of the cell membrane of the hosts
false, should be true
29
29) Infective prions replicate in the cytoplasm of the neurons
true
30
30) Infective prions are taken per os
true
31
31) Encephalitis is typical in the case of transmissible encephalopathies
false
32
32) Protease breaks down prions
false
33
transmissible encephalopathies are acute or per-acute diseases
false
34
34) Antibodies to prions cannot be detected in the case of transmissible encephalopathies
true
35
35) Allergy tests are widely used to diagnose transmissible encephalopathies
false
36
1) Scrapie has genetic predisposition
true
37
2) Scrapie prion is shed in discharges of the infected animals
true
38
3) The EU is free from Scrapie
false
39
4) Scrapie is a zoonotic disease
false
40
5) Atypical scrapie strains are not shed by the infected animals
true
41
6) Scrapie prion is detected with PCR
false
42
7) Scrapie is a disease of sheep, goats, and cattle
false
43
8) Scrapie is mainly seen in sheep between 1.5 and 5 years of age
true
44
9) Itching is a frequent sign of scrapie
true
45
10) Both typical and atypical scrapie strains can cause itching
false
46
11) Scrapie has more clinical signs in lambs than adult sheep
false
47
12) Certain genotypes of sheep are resistant against Scrapie prion
true
48
13) Scrapie is spreading with per os infection
true
49
14) Genetic predisposition is needed for scrapie to develop
true
50
15) Atypical scrapie strains can cause the same clinical signs as typical scrapie
false
51
16) Scrapie can be prevented with live vaccines
false
52
17) Scrapie sensitivity depends on genotype of sheep
true
53
18) Scrapie can be transmitted between sheep in a flock
true
54
19) Itching is always a clinical sign of scrapie
false
55
20) In scrapie we can observe lameness.
false
56
21) Scrapie occurs only in Britain and Ireland.
false
57
22) Sheep cannot shed the scrapie prion
false
58
23) Clinical signs of scrapie are most frequent in animals between 6 and 12 months of age
false
59
24) Scrapie is seen only in adult sheep
false
60
25) Scrapie is seen in sheep and goats
true
61
26) Goat are resistant to scrapie
false
62
27) Scrapie is spread within the flock from animal to animal
true
63
28) Scrapie prion can infect susceptible animals per os
true
64
29) Itching can be seen in the case of typical scrapie
true
65
30) Itching can be seen in the case of atypical scrapie.
false
66
31) Certain sheep can be resistant to scrapie
true
67
32) Scrapie can be prevented with inactivated vaccines
false
68
33) Scrapie prion is shed by the infected animals
true
69
34) Scrapie can be prevented by using attenuated vaccines
false
70
1) There is a per os infection in the case of transmissible mink encephalopathy
true
71
2) The behaviour of the animals is changed in the case of transmissible mink encephalopathy
true
72
3) Transmissible Mink encephalopathy can be transmitted by eating infected meat
true
73
4) Transmissible Mink encephalopathy symptoms: being anxious
true
74
5) Minks are infected with transmissible mink encephalopathy prion per os
true
75
6) Minks shed the transmissible mink encephalopathy prion in the faeces
false
76
7) Movement disorders are typical signs of transmissible mink encephalopathy
true
77
1) Aggressiveness is a clinical sign of BSE
true
78
2) BSE prion causes meningoencephalitis
false
79
3) Clinical signs of BSE appear in cattle slowly
true
80
4) Movement disorders are typical clinical signs of BSE
true
81
5) BSE prion is shed in milk in large amount
false
82
6) BSE prion generally infects cattle in aerosol
false
83
7) BSE prion travels along the nerves from the gut to the brain
true
84
8) BSE infects animals per os
true
85
9) Enteritis and haemorrhages can be seen postmortem in BSE cattle
false
86
10) Hyperaesthesia is a clinical sign of BSE
true
87
11) Calves of cows infected with BSE are frequently infected, they have to be destroyed
false
88
12) There is no vaccine for the prevention of BSE
true
89
13) Ataxia is a clinical sign of BSE
true
90
14) BSE is a zoonotic disease
true
91
15) BSE is spreading fast in the infected herd
false
92
16) Clinical signs of BSE can be seen mainly in 1-1.5 years old cattle
false
93
17) For Bovine spongiform encephalopathy laboratory examination, we use ELISA
true
94
18) In Bovine spongiform encephalopathy the meat contains high number of prions
true
95
19) Creutzfeldt Jakob syndrome is a new type of Bovine spongiform encephalopathy in humans
false, both TSEs - maybe (variant) vCJD
96
20) BSE prions are shed in the faeces and it is transmitted to other cattle in the herd
false
97
21) The incubation time of BSE is 3-5 years
true
98
22) Only a few animals show clinical signs of BSE in an infected herd
true
99
23) Bovine spongiform encephalopathy is widespread in Europe; it is common in most European countries
false
100
24) BSE is not spreading from animal to animal
true
101
25) In the case of BSE polioencephalitis is the main post mortem lesion
false
102
26) BSE prion is mainly detected with PCR
false
103
the agent of bovine spongiform encephalopathy is not shed by the infected animals
true
104
28) Antibodies against bovine spongiform encephalopathy are detected with ELISA.
false
105
29) The agent of bovine spongiform encephalopathy is spreading along the nerves in the infected animals
true
106
30) The agent of bovine spongiform encephalopathy is shed in large number in the milk
false
107
31) Changed behaviour is a typical sign of bovine spongiform encephalopathy
true
108
32) In case of spongiform encephalopathies micro abscesses are in the brain stem
false
109
33) Spongiform encephalopathies are mainly acute diseases.
false
110
34) In the case of spongiform encephalopathies there is encephalitis
false
111
35) Spongiform encephalopathies can be diagnosed by detecting circulating antibodies
false
112
36) In the case of spongiform encephalopathies the behaviour of the animal is generally changed
true
113
37) In the case of spongiform encephalopathies encephalitis is the main post mortem lesion
false
114
38) In the case of spongiform encephalopathies high levels of antibodies is produced
false
115
39) Spongiform encephalopathies are caused by prions
true
116
40) Bovine spongiform encephalopathy cannot infect humans
false
117
41) Bovine spongiform encephalopathy causes aggression
true
118
42) You can diagnose bovine spongiform encephalopathy with ELISA
true
119
43) Bovine spongiform encephalopathy causes an immune response
false
120
44) Bovine spongiform encephalopathy is a contact infection
false
121
45) BSE can be seen in calves from the age of 6 months
false
122
46) Hypersensitivity is a clinical sign of BSE
true
123
47) Focal necrosis in the liver is a typical post mortem lesion of BSE
false
124
2-6 months old calves having BSE are frequently aggressive
false
125
49) Bovine spongiform encephalopathy is seen only in beef cows
false
126
50) Cattle with bovine spongiform encephalopathy have movement difficulties
true
