Transmissible Encephalopathies

Question 1

1) Transmissible encephalopathies can be diagnosed by detecting infective prions in the brain.

Answer 1

true

Question 2

2) In the case of transmissible encephalopathies lesions can only be seen in the central nervous system

Answer 2

true?

Question 3

3) Prion diseases can be diagnosed by detecting the antibodies with ELISA

Answer 3

false, not Ab but Prion Protein threats

Question 4

4) There are major differences in the amino acid sequence of the normal and infective prions

Answer 4

false

Question 5

5) Spongiform encephalopathies of animals occur worldwide except Australia and New Zealand

Answer 5

true

Question 6

6) Prions can become infective prions as a result of a mutation

Answer 6

true

Question 7

7) In the case of transmissible encephalopathies always degenerative lesions can be seen

Answer 7

true

Question 8

8) In the case of transmissible encephalopathies meningoencephalitis is a typical postmortem lesion

Answer 8

false

Question 9

9) Infective prions are resistant against the usual concentration of disinfectants

Answer 9

true

Question 10

10) Agents of transmissible encephalopathies are most frequently detected with PCR

Answer 10

false

Question 11

11) Weight loss is a clinical sign of Transmissible encephalopathies

Answer 11

true

Question 12

12) ELISA can be used for the detection of infective prions in the brain

Answer 12

true

Question 13

13) The folding of normal and the infective prion is different

Answer 13

true

Question 14

14) Infective prions are resistant against proteases

Answer 14

true

Question 15

15) Infective prions can survive 100 °C.

Answer 15

true

Question 16

16) Prions consist of protein and DNA

Answer 16

false

Question 17

17) Chronic prion has no nucleic acid inside

Answer 17

true

Question 18

18) Chronic prion is inactivated by boiling

Answer 18

false

Question 19

19) Chronic prion form has other form than normal prions

Answer 19

true

Question 20

20) Prions contain protein and DNA

Answer 20

false

Question 21

21) Infection with infective prions generally happens per os

Answer 21

false, should be true

Question 22

22) Transmissible encephalopathies are slow diseases

Answer 22

true

Question 23

23) In the case of transmissible encephalopathies encephalitis can be seen in the grey material of the brain

Answer 23

false

Question 24

24) Transmissible encephalopathies are caused by prions

Answer 24

true

Question 25

25) PCR is used to the detection of prions

Answer 25

false

Question 26

26) Prions always cause viraemia in the infected hosts

Answer 26

false

Question 27

27) Prions are spreading in the host along the nerves

Answer 27

true

Question 28

28) Normal prions are essential components of the cell membrane of the hosts

Answer 28

false, should be true

Question 29

29) Infective prions replicate in the cytoplasm of the neurons

Answer 29

true

Question 30

30) Infective prions are taken per os

Answer 30

true

Question 31

31) Encephalitis is typical in the case of transmissible encephalopathies

Answer 31

false

Question 32

32) Protease breaks down prions

Answer 32

false

Question 33

transmissible encephalopathies are acute or per-acute diseases

Answer 33

false

Question 34

34) Antibodies to prions cannot be detected in the case of transmissible encephalopathies

Answer 34

true

Question 35

35) Allergy tests are widely used to diagnose transmissible encephalopathies

Answer 35

false

Question 36

1) Scrapie has genetic predisposition

Answer 36

true

Question 37

2) Scrapie prion is shed in discharges of the infected animals

Answer 37

true

Question 38

3) The EU is free from Scrapie

Answer 38

false

Question 39

4) Scrapie is a zoonotic disease

Answer 39

false

Question 40

5) Atypical scrapie strains are not shed by the infected animals

Answer 40

true

Question 41

6) Scrapie prion is detected with PCR

Answer 41

false

Question 42

7) Scrapie is a disease of sheep, goats, and cattle

Answer 42

false

Question 43

8) Scrapie is mainly seen in sheep between 1.5 and 5 years of age

Answer 43

true

Question 44

9) Itching is a frequent sign of scrapie

Answer 44

true

Question 45

10) Both typical and atypical scrapie strains can cause itching

Answer 45

false

Question 46

11) Scrapie has more clinical signs in lambs than adult sheep

Answer 46

false

Question 47

12) Certain genotypes of sheep are resistant against Scrapie prion

Answer 47

true

Question 48

13) Scrapie is spreading with per os infection

Answer 48

true

Question 49

14) Genetic predisposition is needed for scrapie to develop

Answer 49

true

Question 50

15) Atypical scrapie strains can cause the same clinical signs as typical scrapie

Answer 50

false

Question 51

16) Scrapie can be prevented with live vaccines

Answer 51

false

Question 52

17) Scrapie sensitivity depends on genotype of sheep

Answer 52

true

Question 53

18) Scrapie can be transmitted between sheep in a flock

Answer 53

true

Question 54

19) Itching is always a clinical sign of scrapie

Answer 54

false

Question 55

20) In scrapie we can observe lameness.

Answer 55

false

Question 56

21) Scrapie occurs only in Britain and Ireland.

Answer 56

false

Question 57

22) Sheep cannot shed the scrapie prion

Answer 57

false

Question 58

23) Clinical signs of scrapie are most frequent in animals between 6 and 12 months of age

Answer 58

false

Question 59

24) Scrapie is seen only in adult sheep

Answer 59

false

Question 60

25) Scrapie is seen in sheep and goats

Answer 60

true

Question 61

26) Goat are resistant to scrapie

Answer 61

false

Question 62

27) Scrapie is spread within the flock from animal to animal

Answer 62

true

Question 63

28) Scrapie prion can infect susceptible animals per os

Answer 63

true

Question 64

29) Itching can be seen in the case of typical scrapie

Answer 64

true

Question 65

30) Itching can be seen in the case of atypical scrapie.

Answer 65

false

Question 66

31) Certain sheep can be resistant to scrapie

Answer 66

true

Question 67

32) Scrapie can be prevented with inactivated vaccines

Answer 67

false

Question 68

33) Scrapie prion is shed by the infected animals

Answer 68

true

Question 69

34) Scrapie can be prevented by using attenuated vaccines

Answer 69

false

Question 70

1) There is a per os infection in the case of transmissible mink encephalopathy

Answer 70

true

Question 71

2) The behaviour of the animals is changed in the case of transmissible mink encephalopathy

Answer 71

true

Question 72

3) Transmissible Mink encephalopathy can be transmitted by eating infected meat

Answer 72

true

Question 73

4) Transmissible Mink encephalopathy symptoms: being anxious

Answer 73

true

Question 74

5) Minks are infected with transmissible mink encephalopathy prion per os

Answer 74

true

Question 75

6) Minks shed the transmissible mink encephalopathy prion in the faeces

Answer 75

false

Question 76

7) Movement disorders are typical signs of transmissible mink encephalopathy

Answer 76

true

Question 77

1) Aggressiveness is a clinical sign of BSE

Answer 77

true

Question 78

2) BSE prion causes meningoencephalitis

Answer 78

false

Question 79

3) Clinical signs of BSE appear in cattle slowly

Answer 79

true

Question 80

4) Movement disorders are typical clinical signs of BSE

Answer 80

true

Question 81

5) BSE prion is shed in milk in large amount

Answer 81

false

Question 82

6) BSE prion generally infects cattle in aerosol

Answer 82

false

Question 83

7) BSE prion travels along the nerves from the gut to the brain

Answer 83

true

Question 84

8) BSE infects animals per os

Answer 84

true

Question 85

9) Enteritis and haemorrhages can be seen postmortem in BSE cattle

Answer 85

false

Question 86

10) Hyperaesthesia is a clinical sign of BSE

Answer 86

true

Question 87

11) Calves of cows infected with BSE are frequently infected, they have to be destroyed

Answer 87

false

Question 88

12) There is no vaccine for the prevention of BSE

Answer 88

true

Question 89

13) Ataxia is a clinical sign of BSE

Answer 89

true

Question 90

14) BSE is a zoonotic disease

Answer 90

true

Question 91

15) BSE is spreading fast in the infected herd

Answer 91

false

Question 92

16) Clinical signs of BSE can be seen mainly in 1-1.5 years old cattle

Answer 92

false

Question 93

17) For Bovine spongiform encephalopathy laboratory examination, we use ELISA

Answer 93

true

Question 94

18) In Bovine spongiform encephalopathy the meat contains high number of prions

Answer 94

true

Question 95

19) Creutzfeldt Jakob syndrome is a new type of Bovine spongiform encephalopathy in humans

Answer 95

false, both TSEs - maybe (variant) vCJD

Question 96

20) BSE prions are shed in the faeces and it is transmitted to other cattle in the herd

Answer 96

false

Question 97

21) The incubation time of BSE is 3-5 years

Answer 97

true

Question 98

22) Only a few animals show clinical signs of BSE in an infected herd

Answer 98

true

Question 99

23) Bovine spongiform encephalopathy is widespread in Europe; it is common in most European countries

Answer 99

false

Question 100

24) BSE is not spreading from animal to animal

Answer 100

true

Question 101

25) In the case of BSE polioencephalitis is the main post mortem lesion

Answer 101

false

Question 102

26) BSE prion is mainly detected with PCR

Answer 102

false

Question 103

the agent of bovine spongiform encephalopathy is not shed by the infected animals

Answer 103

true

Question 104

28) Antibodies against bovine spongiform encephalopathy are detected with ELISA.

Answer 104

false

Question 105

29) The agent of bovine spongiform encephalopathy is spreading along the nerves in the infected animals

Answer 105

true

Question 106

30) The agent of bovine spongiform encephalopathy is shed in large number in the milk

Answer 106

false

Question 107

31) Changed behaviour is a typical sign of bovine spongiform encephalopathy

Answer 107

true

Question 108

32) In case of spongiform encephalopathies micro abscesses are in the brain stem

Answer 108

false

Question 109

33) Spongiform encephalopathies are mainly acute diseases.

Answer 109

false

Question 110

34) In the case of spongiform encephalopathies there is encephalitis

Answer 110

false

Question 111

35) Spongiform encephalopathies can be diagnosed by detecting circulating antibodies

Answer 111

false

Question 112

36) In the case of spongiform encephalopathies the behaviour of the animal is generally changed

Answer 112

true

Question 113

37) In the case of spongiform encephalopathies encephalitis is the main post mortem lesion

Answer 113

false

Question 114

38) In the case of spongiform encephalopathies high levels of antibodies is produced

Answer 114

false

Question 115

39) Spongiform encephalopathies are caused by prions

Answer 115

true

Question 116

40) Bovine spongiform encephalopathy cannot infect humans

Answer 116

false

Question 117

41) Bovine spongiform encephalopathy causes aggression

Answer 117

true

Question 118

42) You can diagnose bovine spongiform encephalopathy with ELISA

Answer 118

true

Question 119

43) Bovine spongiform encephalopathy causes an immune response

Answer 119

false

Question 120

44) Bovine spongiform encephalopathy is a contact infection

Answer 120

false

Question 121

45) BSE can be seen in calves from the age of 6 months

Answer 121

false

Question 122

46) Hypersensitivity is a clinical sign of BSE

Answer 122

true

Question 123

47) Focal necrosis in the liver is a typical post mortem lesion of BSE

Answer 123

false

Question 124

2-6 months old calves having BSE are frequently aggressive

Answer 124

false

Question 125

49) Bovine spongiform encephalopathy is seen only in beef cows

Answer 125

false

Question 126

50) Cattle with bovine spongiform encephalopathy have movement difficulties

Answer 126

true