Topic 7 - Membrane 2

Question 1

Integral proteins can only be extracted how?

Answer 1

Organic solvents / detergents

Question 2

name an example of an integral protein with a single TM domain

Answer 2

Glycophorin A

Question 3

Glycophorin A has how many TM domains?

How many AA in how many domains?

Answer 3

1 TM domain

131 AA in 3 domains

Question 4

What happens to the glycophorin A hydrophillic domain?

Answer 4

glycosylated

Question 5

Name an example of an integral protein with multiple TM domains

Answer 5

Bacteriorhodopsin

Question 6

Bacteriorhodopsin membrane has how many AA

Answer 6

45 thick AA membrane

Question 7

Name 4 examples of lipid linked membranes

Answer 7

Prion proteins

viral proteins

Signalling proteins

Insulin receptor

Question 8

What do peripheral(extrinsic) proteins interact with and what do they not interact with?

Answer 8

Interacts with lipid headgroups /other proteins

Doesnt interact with hydrophobic core of bilayer

Question 9

How are peripheral proteins remove?

Answer 9

High salt solution

Question 10

Name 3 examples of peripheral proteins that are cytoskeleton

Answer 10

Spectrin

Actin

Band 4.1

Question 11

Hereditary spherocytopsis is a mutation in whta?

Answer 11

Spectrin / ankyrin genes

Question 12

Name 3 cholinesterase inhibitors for Alzheimer

Answer 12

Aricept

Exelon

Reminyl

Question 13

Name a NMDA receptor antagonist for alzheimers

Answer 13

Ebixa

Question 14

What do cholesterol rich domains contain

Answer 14

cholesterol

Glycospingolipids

sphingomyelin

Question 15

What can be taken that has shown to lower prevalance of alzheimers due to infleunce of altering cholesterol content/fluidity of membrane rafts?

Answer 15

Statins

Question 16

if APP processing occurs at the rafts, what occurs?

Answer 16

Plaque formation

Question 17

if a glycoprotein is O linked, carbohydrate is attached to what AA?

How?

How many sugar residues are present?

Answer 17

Serine / threonine

Hydroxyl group

2-5 sugars

Question 18

N linked glycoproteins have a carbohydrate attached to what AA?

What sequence has to be present though?

Answer 18

Asparagine

Asn - X - Ser/Thr

Question 19

How many sugar residues are present in N linked glycoproteins

Answer 19

30-40

Question 20

N-Acetyl galactosamine is found in what blood group?

Answer 20

A

Question 21

Galactose is found in what blood group?

Answer 21

B

Question 22

What glycoprotein is found in type O?

Answer 22

There isnt any