Topic 7 - Membrane 2 Flashcards
Integral proteins can only be extracted how?
Organic solvents / detergents
name an example of an integral protein with a single TM domain
Glycophorin A
Glycophorin A has how many TM domains?
How many AA in how many domains?
1 TM domain
131 AA in 3 domains
What happens to the glycophorin A hydrophillic domain?
glycosylated
Name an example of an integral protein with multiple TM domains
Bacteriorhodopsin
Bacteriorhodopsin membrane has how many AA
45 thick AA membrane
Name 4 examples of lipid linked membranes
Prion proteins
viral proteins
Signalling proteins
Insulin receptor
What do peripheral(extrinsic) proteins interact with and what do they not interact with?
Interacts with lipid headgroups /other proteins
Doesnt interact with hydrophobic core of bilayer
How are peripheral proteins remove?
High salt solution
Name 3 examples of peripheral proteins that are cytoskeleton
Spectrin
Actin
Band 4.1
Hereditary spherocytopsis is a mutation in whta?
Spectrin / ankyrin genes
Name 3 cholinesterase inhibitors for Alzheimer
Aricept
Exelon
Reminyl
Name a NMDA receptor antagonist for alzheimers
Ebixa
What do cholesterol rich domains contain
cholesterol
Glycospingolipids
sphingomyelin
What can be taken that has shown to lower prevalance of alzheimers due to infleunce of altering cholesterol content/fluidity of membrane rafts?
Statins
if APP processing occurs at the rafts, what occurs?
Plaque formation
if a glycoprotein is O linked, carbohydrate is attached to what AA?
How?
How many sugar residues are present?
Serine / threonine
Hydroxyl group
2-5 sugars
N linked glycoproteins have a carbohydrate attached to what AA?
What sequence has to be present though?
Asparagine
Asn - X - Ser/Thr
How many sugar residues are present in N linked glycoproteins
30-40
N-Acetyl galactosamine is found in what blood group?
A
Galactose is found in what blood group?
B
What glycoprotein is found in type O?
There isnt any
