Topic 7- Extracellular Signalling Flashcards
Give an example of juxtracrine signalling
T Helper cell - APC
What protein is found in gap junctions?
Connexin
Name 4 1st messengers
Growth Factors
Neurotransmitters
hormones
cytokines
Give 2 groupings of hydrophillic hormones
catecholamines
Peptide hormones
Name 3 peptide hormones
Imsulin / glucagon / AG2
Name 4 catecholamines
ADrenaline
Dopamine
Serotonin
Histamine
Give an example of sterol hormone
Calcitriol (VitD)
Give 3 groupings of lipid based hormones
Steroids
Thyroid hormones
Sterol hormones
Where are the receptors of lipid based hormones found?
Receptor within cell
What sort of receptor is a ligand gated ion channel
ionotropic receptor
What is the structure of a ligand gated ion channel
4/5 heteromeric subunits
Function of a ligand gated ion channel
fast synaptic transmission
What is a nicotinic acetylcholine receptor class?
Ligand gated ion channel
give examples of ligand gated ion channels
GABA
GlyR
5-HT3R
G coupled protein structure
Metabotropic heptahelical receptor
3 examples of G coupled proteins
mACh receptor
Adrenoreceptors
AG2 receptors
Angiotensinogen is converted into AG1 by what?
Renin
AG1–> AG2
ACE
AG2 structure
Octapeptide
ACE inhibitor
Ramipril
AT1 receptor antagonist
Losartan
Insulin acts through what type of receptor?
Receptor Tyrosine Kinase
Catalytic Receptor
Cytokines act through what type of receptor
Receptor Tyrosine Kinase
Non-Catalytic receptor
What are the two types of nuclear hormone receptors
Intracellular receptors
Monomeric structure receptors
Which end of neuron is at the terminal
Axon
Substance P / Endorphins are what type of neurotransmitters
Peptides
Anadamine is what type of neurotransmitter
Lipid
What is the function of antidepressants
Increase monoaminergics
TCA // SSRI // SNRI are all what?
Monoamine reuptake inhibitors
