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IMS > Topic 7- Extracellular Signalling > Flashcards

Topic 7- Extracellular Signalling Flashcards

1
Q

Give an example of juxtracrine signalling

A

T Helper cell - APC

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2
Q

What protein is found in gap junctions?

A

Connexin

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3
Q

Name 4 1st messengers

A

Growth Factors
Neurotransmitters
hormones
cytokines

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4
Q

Give 2 groupings of hydrophillic hormones

A

catecholamines

Peptide hormones

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5
Q

Name 3 peptide hormones

A

Imsulin / glucagon / AG2

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6
Q

Name 4 catecholamines

A

ADrenaline

Dopamine

Serotonin

Histamine

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7
Q

Give an example of sterol hormone

A

Calcitriol (VitD)

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8
Q

Give 3 groupings of lipid based hormones

A

Steroids

Thyroid hormones

Sterol hormones

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9
Q

Where are the receptors of lipid based hormones found?

A

Receptor within cell

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10
Q

What sort of receptor is a ligand gated ion channel

A

ionotropic receptor

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11
Q

What is the structure of a ligand gated ion channel

A

4/5 heteromeric subunits

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12
Q

Function of a ligand gated ion channel

A

fast synaptic transmission

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13
Q

What is a nicotinic acetylcholine receptor class?

A

Ligand gated ion channel

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14
Q

give examples of ligand gated ion channels

A

GABA

GlyR

5-HT3R

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15
Q

G coupled protein structure

A

Metabotropic heptahelical receptor

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16
Q

3 examples of G coupled proteins

A

mACh receptor

Adrenoreceptors

AG2 receptors

17
Q

Angiotensinogen is converted into AG1 by what?

A

Renin

18
Q

AG1–> AG2

A

ACE

19
Q

AG2 structure

A

Octapeptide

20
Q

ACE inhibitor

A

Ramipril

21
Q

AT1 receptor antagonist

A

Losartan

22
Q

Insulin acts through what type of receptor?

A

Receptor Tyrosine Kinase

Catalytic Receptor

23
Q

Cytokines act through what type of receptor

A

Receptor Tyrosine Kinase

Non-Catalytic receptor

24
Q

What are the two types of nuclear hormone receptors

A

Intracellular receptors

Monomeric structure receptors

25
Q

Which end of neuron is at the terminal

A

Axon

26
Q

Substance P / Endorphins are what type of neurotransmitters

A

Peptides

27
Q

Anadamine is what type of neurotransmitter

A

Lipid

28
Q

What is the function of antidepressants

A

Increase monoaminergics

29
Q

TCA // SSRI // SNRI are all what?

A

Monoamine reuptake inhibitors

IMS (25 decks)

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