Topic 1 (C/mutation)

Question 1

aneuploidy

Answer 1

abnormal number of chromosomes

Question 2

Mutation induction requires what (2)

Answer 2

Chemical modification of DNA

Replication of DNA

Question 3

Hallmarks of Cancer Cells (GF)

Answer 3

Resistant to negative GF

Grows independent of +GF

Question 4

Oncogenes role

Whats happened with cancer

Answer 4

Involved in promoting growth/division

Mutated in cancer

Question 5

With tumour suppressor genes, what has to occur for carcinogenesis to occur

Answer 5

Mutations of both copies

Question 6

Genetics accounts for what % of cancers?

Answer 6

5%

Question 7

Rare inherited Cancer syndrome

Answer 7

Xeroderma pigmentosum

Question 8

name 3 biological agents causes of cancer

Answer 8

Hep B
HPV
H.pylori

Question 9

What is found in cooked meats that can contribute to cancer risk?

What cancer?

Answer 9

Heterocyclic amines in cooked meat

Colon

Question 10

What can UV absorption do to Thymine

what does this lead to?

Answer 10

Lead to a Thymine Dimer that are covalently bonded together

Leads to frameshift mutation

Question 11

Which type of study follows a cohort over time?

Answer 11

Prospective studies

Question 12

Which factor produces the highest cancer rates?

Answer 12

Food