Thyroid hormones

Question 1

Drugs in this class

Answer 1

Levothyroxine - only orally

Liothyronine - has IV

Question 2

Indications of Thyroid hormones

Answer 2

Primary hypothyroidism

Hypothyroidism 2ndry to hypopituitarism

Question 3

Thyroid hormones MOD

Answer 3

Replaces T3 and T4

Question 4

Thyroid hormones SE

Answer 4

If excess can mimic Sx of hyperthyroidism

Gi upset (Diarrhoea, weight loss,vomiting)

palpitations arrhythmias, angina

tremor, restlessness

Question 5

Thyroid hormones warnings

Answer 5

Increase HR and metabolism

Careful with angina

In hypopituitarism start corticosteroids before initiating thyroxine to avoid addisonian crises

Question 6

Thyroid hormones Interactions

Answer 6

Increase dose when cytochrome p450 inducers are taken

Can increase insulin and glucose demand in DM

can enhance effects of warfarin

GI absorption is reduced by antacids, calcium, or iron salts. Take 4 hours apart