Tetracyclines

Question 1

Drugs in the class Tetracyclines

Answer 1

Doxycycline

Lymecycline

Question 2

Indications of Tetracyclines

Answer 2

Acne

Exacebrations of COPD

Atypical/typical pneumonia

Pelvic Inflammatory disease - chlamydia

Question 3

Mechanism of action of Tetracyclines

Answer 3

Inhibit bacterial protein synthesis by binding to 30S

They inhibit transfer RNA to joint messenger RNA

Becoming bacteriostatic

Question 4

Side effects of Tetracyclines

Answer 4

Nausea, vomiting, diarrohoea

Allergy

Discolouration or hypoplasia of tooth enemal if given to children

Intercranial hypertension - very rare

Photosensitivity

Oesophageal irritation, dysphagia, ulcers

Question 5

Warnings of Tetracyclines

Answer 5

Pregnancy

Breast feeding

Children <12yrs

Renal impairment

Question 6

Interactions of Tetracyclines

Answer 6

Should not be given within 2 hours of calcium, iron, or antacids

Kills gut flora so increases efficacy of warfarin.