Metronidazole Flashcards
1
Q
Drugs of the class Metronidazole
A
class in table is anaerobic antimicrobials
2
Q
Indications of Metronidazole
A
Abx-associated colitis
oral infections - dental abscess or aspiration pneumonia
surgical and gynaecological infections
protozoal infections
3
Q
MOD of Metronidazole
A
Metronidazole enters bacterial cells by passive diffusion
in anaerobic bacteria - binds to dna, dna degradation and cell death
4
Q
SE of Metronidazole
A
GI upset (N/V)
peripheral and optic neuropathy
seizures
encephalopathy
5
Q
Warnings of Metronidazole
A
Metabolised by p450 - low dose in pts with severe liver
dont drink alcohol when taking
6
Q
Interactions of Metronidazole
A
some inhibatory effect on p450
p450 inducers too
