Glycopeptides

Question 1

drugs of glycopeptides class

Answer 1

Vancomycin - best for MRSA

orall for Cdiff

IV for others

Question 2

Indications of Vancomycin

Answer 2

Treatment of gram-ve infections if severe or penicillin contraindicated

treatment for Abx-associated colitis by Cdiff - usually 2nd line when metronidazole is ineffective

Question 3

SE of Vancomycin

Answer 3

thrombophelbitis is the most common SE

red man syndrome - when it is infused rapidly

IV can cause nephrotoxicity, ototoxicity, and blood disorders

Question 4

MOD of Vancomycin

Answer 4

Vancomycin inhibits growth and cross-linking between peptidoglycan chains, inhibiting synthesis of cell walls of gram+ve bacteria

Inactive against most gram-ve bacteria

Question 5

Warnings of Vancomycin

Answer 5

careful monitoring of plasma drug concentration

renal impairment and elderly

Question 6

Interactions of Vancomycin

Answer 6

aminglycosides, loop diuretics and ciclosporin (immunsuppresent) increase risk of ototoxicity and/or nephrotoxicity