Quinolones

Question 1

Drugs of the class Quinolones

Answer 1

Ciprofloxacin

Moxifloxacin

Levofloxacin

Question 2

Indications of Quinolones

Answer 2

UTI

Severe GI infection

lower RTI

Ciprofloxacin is the only oral antibiotic that is affective against pseudomonas aeruginosa

Question 3

MOD of Quinolones

Answer 3

Kill bacteria by inhibiting DNA synthesis.

Effective against gram-ve explaining their utility in GI and GU

Moxilfoxacin and levofloxacin are new drugs that have gram+ve activity making them able to treat LRTI

Question 4

SE of Quinolones

Answer 4

generally well tolerated

GI upset

inflamation and rupture of muscle tendons

quinlones (especilally moxi) prolongs QT interval –> increased risk of arythmia

high risk of Cdiff

Question 5

Warnings of Quinolones

Answer 5

pts with seizures

pts with risk factors of QT prolongation

Question 6

Interactions of Quinolones

Answer 6

ciprofloxacin ihibits certain p450 drugs increasing risk of toxicity especially theophyline

dont use with drugs that prolong QT like macrolides

Question 7

Tell me about Quinolones use

Answer 7

Usually kept for second or third line treatment because of the rapid development of resistance and the risk of C diff

Question 8

tell me about Ciprofloxacin

Answer 8

only oral Abx effective against pseudomonas aeruginosa

ciprofloxacin inhibits certain p450 drugs increasing risk of toxicity especially theophyline

Question 9

co-prescription of Quinolones with NSAIDs

Answer 9

increase risk of seizures

Question 10

co-prescription of Quinolones with predinisolone

Answer 10

increase risk of tendon rupture