Antiemetics

Question 1

Drugs in this class (Antiemetics)

Answer 1

Metoclopramide

domperidone

Question 2

Indications of Antiemetics

Answer 2

Prophhylaxis and treatment Nausea and vomiting

Primarily for reduced gut motility

Question 3

Mechanism of action of Antiemetics

Answer 3

dopamine acts on D2, the main receptors in the chemoreceptor trigger zone (CTZ) (responsible for detecting drugs in gut)

blocking D2 receptors have a prokinetic effect –> promoting gastric emptying thus there antiemetic effect

Question 4

Warnings of Antiemetics

Answer 4

Children Young adults –> more prone to exrapyramidial syndromes

GI obstruction Perforation –> because of prokinetic effect

Question 5

interactions Antiemetics

Answer 5

increases risk of extrapyramidial effects if metaclopremide is combined with antipsychotics

in parkinsonisms dont use with dopaminergic agents –> will antagonise (inhibits) effect

domperidone is not subject to these

Question 6

Side effects of Antiemetics

Answer 6

Diarrohoea most common side effect of blocking D2 –> because blocking it promotes emptying

Parkinsonism

Question 7

Side effects of Antiemetics

Answer 7

Diarrohoea most common side effect of blocking D2 –> because blocking it promotes emptying

Parkinsonism, extrapyrimidial syndromes