loop diuretics

Question 1

Drugs in the class Loop diuretics

Answer 1

Furosemide

Bumetanide

Question 2

Indications of Loop diuretics

Answer 2

Relief of breathlessness in acute pulmonary oedema, with O2 and nitrates

Sx relief of fluid overload in chronic HF

Sx relief of fluid overload in other oedema causes

Question 3

MOD of Loop diuretics

Answer 3

Act on loop of Henle and inhibit Na/K/Cl co-transporters

Question 4

SE of Loop diuretics

Answer 4

Dehydration and hypotension of increased water losses

Low electrolyte state

Hearling loss and tinnitus

Question 5

Warnings of Loop diuretics

Answer 5

Hypovalaemia

Dehydration

Hepatic encephalopathy

Hypokalaemia

Hyponatraemia

Gout

Question 6

Interactions of Loop diuretics

Answer 6

affect drugs excreted by kidneys

Lithium lvls increase

digoxin lvl increase

increase ototoxicity and nephrotoxicity of aminoglycosides