Aminoglycosides Flashcards
1
Q
Indication of Aminoglycosides
A
Severe sepsis
Billary and intra-abdominal sepsis
Pyelonephritis and complicated UTI
Endocarditis
2
Q
When is combination therapy needed for Aminoglycosides
A
When organism unknown because they are not effective against streptoccoci and anaerobes
Combine with Penicillin or Metronidazole
3
Q
Mechanism of action of Aminoglycosides
A
They irreversibly bind to 30S
Inhibit protein synthesis
4
Q
Side effects of Aminoglycosides
A
Nephrotoxicity
Ototoxicity
5
Q
Warnings of Aminoglycosides
A
Renal impairment
Elderly
Neonates
Myasthenia graves
6
Q
Interactions of Aminoglycosides
A
Ototoxicity risk increases with loop diuretics or vancomycin
Nephrotoxocity with Cyclosporine vancomycin cephalosporins
7
Q
Drugs of the class Aminoglycosides
A
Gentamicin
Amikacin
