Amitriptyline Flashcards
1
Q
Drugs in the class tricyclic antidepressants
A
Amitriptyline
lofepramine
2
Q
Indications of tricyclic antidepressants
A
2nd line for moderate-severe depression if SSRI (1st line) contraindicated but less often used now
use more frequently for neuropathic pain
3
Q
MOD of tricyclic antidepressants
A
Inhibit neuronal reuptake of serotonin (5-HT) and noradrenaline
Block a wide array of receptors - causing many SE
4
Q
SE of tricyclic antidepressants
A
dry mouth
constipation
urinary retention
hypotension
Drowsiness
ECG changes
Sudden withdrawal is bad
5
Q
Warnings of tricyclic antidepressants
A
elderly
CVS
Constipation
prostatic hypertrophy
raised intraocular pressure
6
Q
Interactions of tricyclic antidepressants
A
Dont with monoamine oxidase inhibitor - both work the same
