Penicillins

Question 1

Indications of penicillin

Answer 1

Tonsilitis

Pneumonia

Endocarditis and skin and soft tissue infection

Clostridium infection for example tetanus

Meningococcal infection - meningitis, septicaemia

Question 2

Drugs of the class penicillin

Answer 2

Amoxicillin

Benzylpenicillin

Tazobactam/tazocin

Question 3

Side effects of penicillin

Answer 3

Allergy 1-10% of people. which present as a rash or a anaphylactic reaction.

CNS toxicity

Question 4

Contra-indications of penicillin

Answer 4

Renal impairment

History of penicillin allergy

Question 5

Interactions of Penicillin

Answer 5

reduce renal excretion of methotroxate which increases risk of toxicity

Question 6

Mechanism of action of Penicillins

Answer 6

Inhibits the enzyme responsible for cross-linking peptidoglycans in bacterial cell walls.

This weakens cell walls.

Therefore –> cell swelling, lysis, and death

Penicillins beta lactam ring.

Question 7

What is the relationship between beta lactams and penicillin

Answer 7

penicillin containt beta lactam chains which is responsible for their antimicrobial activity.

Bacter resist penicillin by making beta lactamase which break these chains.