Macrolides

Question 1

Drugs in the class Macrolides

Answer 1

Clarithromycin

Erythromycin

azithromycin

Question 2

SE Macrolides

Answer 2

usually with erythromycin

Macrolides are irritants causing nausea, vomiting, abdominal pain when taking orally and thrombophlebitis if IV

Allergy

antibiotic associated colitis

cholestatic jaundice

prolongation if QT interval

ototoxicity with high doses

Question 3

MOD Macrolides

Answer 3

inhibit bacterial protein synthesis by binding to 50S subunit of bacterial ribosome and block translocation

Bacteriostatic

Question 4

Interactions Macrolides

Answer 4

erythromycin and clarithromycin inhibit p450 (not azithromycin)

caution with pts taking QT prolonging medication or cause arrythmias.

Question 5

Warnings of Macrolides

Answer 5

severe hepatic

low dose severe renal

Question 6

which macrolide doesnt inhibit p450

Answer 6

aizthromycin

Question 7

which macrolide doesn’t inhibit p450

Answer 7

aizthromycin