Aminosalicylates Flashcards
1
Q
Drugs of the class Aminosalicylates
A
Mesalazine
Olsalazine
Sulfasalazine (SSZ)
2
Q
Indications of Aminosalicylates
A
Mesalazine (replaced Sulfasalazine) is first line treatment for mild to moderate IBD.
Sulfasalazine is used as a DMARD in treatment of Rheumatoid arthritis, usually as part of complication therapy
3
Q
Mechanism of action of Aminosalicylates
A
Release 5-aminosalicyclic acid
has both anti-inflamatory and immunosuppressive effects
They act topically on the gut and not systemically
4
Q
Warnings of Aminosalicylates
A
Mesalazine and sulfasalazine are Salicylates. Like aspirin they shouldnt be given to patients with aspirin allergy
5
Q
Interactions of Aminosalicylates
A
Ph altering medications (PPI and Lactulose)
