Carbimazole

Question 1

Drugs of this class

Answer 1

It is of the class antithyroids, another one is Propylthiouracil

Question 2

Indications of Carbimazole

Answer 2

Thyrotoxicosis

Question 3

Side effects of Carbimazole

Answer 3

Feeling sick (nausea), stomach upset

Changes to the way things taste, hair loss

Skin rash, itching

Headache, muscle and joint pain

Reduces WCC

Question 4

Carbimazole MOD

Answer 4

It is a prodrug that is converted into Methimazole

Methimazole prevents thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

Question 5

Carbimazole contraindications

Answer 5

Serious, pre-existing haematological conditions. Severe hepatic impairment.

Question 6

Carbimazole interactions

Answer 6

Increased serum levels of theophylline or may develop toxicity. May enhance the effect of anticoagulants.