Potassium sparring diuretics

Question 1

Drugs of the class Potassium sparring diuretics

Answer 1

Amiloride

co-amilofruse - with furosemide

co-amilozide - with thiazide

Question 2

indications of Potassium sparring diuretics

Answer 2

Combination therapy for hypokalaemia caused by loop or thiazide diuretics

Question 3

What is spironolactone

Answer 3

It is an aldosterone antagonists but it has Potassium sparring effects

Question 4

MOD Potassium sparring diuretics

Answer 4

relatively weak diuretics alone

in combination with other diuretics they can counteract potassium loss

acts on distal convulted tubules - inhibits reasborption of sodium by epithelial sodium channels

Question 5

SE Potassium sparring diuretics

Answer 5

uncommon at low doses

GI upset

with other diuretics - dizzy, hypotension, urinary Sx

risk of hypo/hyperkalaemia or hyponatreamia should not be ignored

Question 6

Warnings of Potassium sparring diuretics

Answer 6

Avoid in severe renal

hyperkalaemia

hypokalaemia - should not be start with it

like other diuretics avoid in state of volume depletion

Question 7

Interactions of Potassium sparring diuretics

Answer 7

dont use with other potassium elevating drugs - potassium supplements and aldosterone antagonists

digoxin and lithium renal clearance may be altered

Question 8

Why monitor U&Es when adding Spironolactone in step4 HTN treatment

Answer 8

Because of risk of hyperkalaemia and hyponatreamia since potassium retention is increased with Spironolactone but sodium and water is excreted