The MHC and Transplantation (Core Immunology) Flashcards
1
Q
What is MHC?
A
MHC is a gene that codes for HLA proteins. MCH proteins are used to present self and non-self antigens to T cells.
2
Q
Where are Class 1 MHC antigens found?
A
on all nucleated cells
3
Q
Where are Class 2 MHC antigens found?
A
mainly on B cells but also on T cells
4
Q
How are the inherited antigens (HLA) displayed on the cell surface?
A
Co-dominant expression ie. All the inherited antigens (HLA) are expressed
5
Q
What is sensitisation?
A
Sensitisation is any event which elicits a HLA directed immune response
6
Q
What is hyperacute rejection?
A
Is when the immune system attacks the transplant by activating the clotting cascade (stops blood supply) and complement cascade (immune)