The MHC and Transplantation (Core Immunology) Flashcards

1
Q

What is MHC?

A

MHC is a gene that codes for HLA proteins. MCH proteins are used to present self and non-self antigens to T cells.

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2
Q

Where are Class 1 MHC antigens found?

A

on all nucleated cells

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3
Q

Where are Class 2 MHC antigens found?

A

mainly on B cells but also on T cells

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4
Q

How are the inherited antigens (HLA) displayed on the cell surface?

A

Co-dominant expression ie. All the inherited antigens (HLA) are expressed

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5
Q

What is sensitisation?

A

Sensitisation is any event which elicits a HLA directed immune response

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6
Q

What is hyperacute rejection?

A

Is when the immune system attacks the transplant by activating the clotting cascade (stops blood supply) and complement cascade (immune)

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