Acute Leukaemia Flashcards
What is acute laukaemia?
Cancer of the white blood cells
What are the 2 subgroups of acute leukaemia?
1) Acute myeloid leukaemia (AML)
2) Acute Lymphoblastic Leukaemia
What is acute myeloid leukaemia?
Cancer of the myeloid cells, this includes :
- macrophages
- neutrophils
- eosinophils
- basophils
- erythrocytes
- dendritic cells
- platelets
ect. …
What is acute lymphoblastic leukaemia?
Cancer of the lymphocytes
What are the key clinical features of acute leukaemia?
- Anaemia
- Infection
- Bruising
- Haemorrhage
What are the immunological markers of acute leukaemia?
1) monoclona antibody determination of surface antigen expression
2) Immunoflouresence
what is the significance of the Philadelphia Chromosome in leukaemia?
Philadelphia chromosome: t(9;22) translocation is a specific genetic abnormality in chromosome 22 of leukemia cancer cells.
In what disease does the following genetic abnormalities provide a good prognosis with - t(8;21) and t(15:17)
acute myeloid leukaemia
In what disease does t(9;22) gene abnormality provide a bad prognosis?
Acute lympoblastic leukaemia
