Myeloma and Lymphoma (haemotology pathology)

Question 1

What investigative process enables the detection and identification of monoconal antibodies

Answer 1

Immunofixation

Question 2

What is an incurable malignant disorder of clonal plasma cells called?

• the median age of presentation of this disease is 70years.
• *it has a higher incidence amoung Afro-caribbean ethnic groups

Answer 2

Myeloma

Question 3

What is MGUS?

Answer 3

Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein — known as monoclonal protein or M protein — is in your blood.
The protein is produced in a type of white blood cell (plasma cells) in your bone marrow.
MGUS usually causes no problems.

Question 4

What is amyloidosis?

Answer 4

Amyloidosis is the deposition of amyloid in the body.

Question 5

What is follicular lymphoma?

Answer 5

neoplastic disorder of lymphoid tissue.

it is a type of non-hodgkin lymphoma that is characterised by slowly enlarging lymph nodes.

Question 6

What is a type of non-hodgkin lymphoma that is characterised by slowly enlarginh lymph nodes?

Answer 6

Follicular lymphoma

Question 7

What is hodgkin lymphoma?

Answer 7

cancer originates from lymphocytes.

Hodgkin lymphoma, B-lymphocytes multiply in an abnormal way and collect in certain parts of the lymphatic system, such as the lymph nodes. The affected lymphocytes lose their infection-fighting properties, making you more vulnerable to infection.

Question 8

What is non-hodgkin lymphoma?

Answer 8

Any type of lymphoma (except hogkins)

Question 9

What condition is characterized by the increased levels of a certain antibodies in the blood serum?

Answer 9

Polyclonal hypergammaglobulinaemia

Question 10

What is the term for lymph nodes which are abnormal in size, number or consistency

Answer 10

Lymphadenopathy

Question 11

What are the causes of Lymphadenopathy?

Answer 11

1) Infection:
- EBV
- toxoplasmosis
- HIV

2) Tumour (Hodkins / non hodgkin’s lymphoma)

3) Autoimmune
- SLE