Test 2 (Chap 3) Flashcards

1
Q

Galatians 5:1

A

For freedom Christ has set us free; stand firm therefore, and do not submit again to a yoke of slavery.

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2
Q

Active placebo

A

A psychologically inactive drug that has some peripheral side effects that patients may recognize and thereby assume they are receiving actual treatment.

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3
Q

Examples of Active placebo

A

Patients experiencing minor dry mouth, dizziness, or blurred vision.

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4
Q

Agoraphobia

A

Fear of being in open places where a panic attack may occur and from which it would be difficult to escape or help would be unavailable.

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5
Q

Anticonvulsant

A

A drug used to treat seizure disorders. Occasionally used to treat symptoms of bipolar disorder.

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6
Q

Antimanic

A

A drug used to treat bouts of mania or hypomania

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7
Q

Atypical

A

An atypical drug is a class of drug that differs significantly in its mechanism of action from other medication for a particular psychological disorder.

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8
Q

Bipolar disorder

A

A severe mood disorder characterized by depressive and manic episodes.

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9
Q

Brain-derived neurotropic factor (BDNF)

A

A nerve growth factor essential for normal cell survival, receptor growth, and for the growth of new neurons.

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10
Q

CREB (cyclic adenosine monophosphate (or cAMP) response element binding protein)

A

A second messenger activated by metabotropic receptors responsible for transcribing brain-derived neurotropic factor from a cell’s DNA

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11
Q

Deaminate

A

An enzymatic reaction that deactivates a neurotransmitter by removing an essential amine chemical group from its molecular structure.

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12
Q

Downregulation

A

A process that results in a decrease in synaptic activity caused by decreasing neurotransmitter synthesis, its release, and/or its receptor availability

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13
Q

Dysthymic disorder

A

A moderately severe mood disorder that is characterized by lengthy episodes of depression (at least 2 years)

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14
Q

First generation drug

A

the first class of drugs used to treat a particular psychological disorder

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15
Q

Hypomanic episode

A

A period of elevated, expansive, or irritable mood lasting at least four days. Less severe than a manic episode

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16
Q

Lag time

A

The delay of about 10 to 14 days between the onset of medication and observations of symptom relief in depression.

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17
Q

Major depressive disorder

A

A severe mood disorder during which a person experiences depressive episodes without intermittent bouts of mania

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18
Q

Manic episode

A

A period of at least one week of excessively elevated mood, euphoria, or enthusiasm that may be interrupted by outbursts of anger or irritability.

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19
Q

Monoamine hypothesis

A

The proposal that deficiencies in the monoamine neurotransmitters dopamine, norepinephrine, and/or serotonin cause depression.

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20
Q

Monoamine oxidase inhibitors (MAOIs)

A

An antidepressant that blocks the activity of the degrading enzyme monoamine oxidase in the synaptic gap of monoamine neurotransmitters.

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21
Q

Nurogenesis

A

The cellular process that contributes to neuronal growth

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22
Q

Neuropathic pain

A

Associated with damage to, or overuse of, nerves. It may be associated with certain types of cancer, autoimmune disorders, or trauma.

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23
Q

Psychostimulant

A

A drug that increase or stimulates cortical activity and arousal.

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24
Q

What are examples of Psychostimulants

A

Cocaine and amphetamines

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25
Q

Rapid cycling

A

A condition where periods of depression and mania in bipolar disorder cycle at least four times in a year.

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26
Q

Reactive depression

A

A period of depression associated with a significant life event such as the loss of a spouse or significant other, loss of financial resources, or significant stress.

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27
Q

Second generation

A

A class of drugs that have supplemented or replaced first generation drugs and differ significantly in their mechanism of action.

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28
Q

Serotonin syndrome

A

A toxic reaction caused by excessive serotonin activity. Symptoms may include disorientation, confusion, visual disturbances, agitation, and mania

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29
Q

Suicidality

A

Attempts, both successful and unsuccessful, at committing suiide.

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30
Q

Suicide ideation

A

Thoughts of suicide and/or planning suicide attempts

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31
Q

Transcription

A

A step in the process of expressing the activity of genes for the building of a specific protein.

32
Q

Tricyclic antidepressant

A

An antidepressant characterized by its three-ring molecular structure.

33
Q

Upregulation

A

A process that results in an increase in synaptic activity by increasing neurotransmitter synthesis, its release, and/or the availability of its receptors.

34
Q

What is the S in SIGECAPS?

A

Sleep - Too much or too little

35
Q

What is SIGECAPS for?

A

Diagnosing depression

36
Q

What is the I in SIGECAPS

A

Interested - What do you do for fun?

37
Q

What is the G in SIGECAPS

A

Guilt

38
Q

What is the E in SIGECAPS

A

Energy - too much or too little

39
Q

What is the C in SIGECAPS

A

Concentration

40
Q

What is the A in SIGECAPS

A

Appetite - Too much or too little

41
Q

What is the P in SIGECAPS

A

Psychomotor - too much or too little movement

42
Q

What is the second S in SIGECAPS

A

Sex - loose interest in - or Suicide

43
Q

Serotonin Specific Reuptake Inhibitors (SSRIs) drugs

A

1) Celexa
2) Lexapro
3) Prozac
4) Luvox
5) Paxil
6) Zoloft

44
Q

Monoamine Oxidase Inhibitors (MAOIs) drugs

A

1) Marplan
2) Nardil
3) Eldapril
4) Parnate

45
Q

Tricyclic Antidepressant Drugs

A

1) Elavil
2) Norpramin
3) Sinequan
4) Tofranil, Imipramin
5) Pamelor
6) Triptil, Vivactil
7) Surmontil

46
Q

What drug makes you eat alot?

A

Remeron

47
Q

Lexapro

A

escitalopram

48
Q

Celexa

A

citalopram

49
Q

Zoloft

A

sertraline

50
Q

Prozac

A

fluoxetine

51
Q

Paxil

A

paroxetine

52
Q

Serotonin (SE)-Norepinephrine (NE) Reuptake Inhibitors (SNRIs) Drugs

A

1) Cymbalta
2) Remeron
3) Serzone
4) Effexor

53
Q

Atypical antidepressants drugs

A

1) Asendin
2) Wellbutrin/Zyban
3) Ludiomil
4) Norebox, Edronax
5) Desyrel

54
Q

Effexor

A

venlafaxine

55
Q

Pristia

A

desvealafaxin

56
Q

Cymbalta

A

duloxetine

57
Q

Remeron

A

mirtazepine

58
Q

Wellbutrin/Zyban

A

bupropion

59
Q

Desyrel

A

trazodone

60
Q

Esketamine

A

ketamine

61
Q

Tofranil

A

imipramine

62
Q

Elavil

A

amiltriptyline

63
Q

Pamelor

A

nortriptyline

64
Q

Anafranil

A

clomipreminyo

65
Q

Mood stabilizers and anticonvulsant drugs

A

1) Cithium
2) Depalcote
3) Neurontin
4) Lyricm
5) Topomax
6) Tegretol
7) Abilify

66
Q

…. loads the gun but …. pulls the trigger

A

Genetics, Environment

67
Q

What is FIGIPC for?

A

Mania diagnosis

68
Q

What does FIGIPC stand for?

A

Flight of ideas
Impulsiveness
Grandiosity
Insomnia - sometimes first symptom
Pressure of speech - can’t stop speaking
Clanging associations - rymes/lyrics

69
Q

What is the Monoamine Hypothesis?

A

We have too few Monamines (Serotonin, Dopamine, and Norepinephrine).

70
Q

Why was the monoamine hypothesis revised?

A

Because even though antidepressant treatments cause rapid changes in neurotransmitters, there is a lag time between drug-induced changes in neurotransmitter availability and symptoms which can take 2 weeks or longer to improve.

71
Q

How was the Monoamine hypothesis revised?

A

That depression may be a consequence of neural degeneration in the hippocampus and frontal cortex caused by monoamine neurons in these areas failing to produce enough tropic or growth factors. - There is more going on than just monoamine neurotransmitter unavailability

72
Q

What nerve growth factor is believed to play a significant part in the revised monoamine hypothesis?

A

BDNF (brain-derived neurotropic factor)

73
Q

What may contribute to the complication of the monoamine hypothesis?

A

Chronic Stress

74
Q

Who came up with the BDNF theory?

A

Ronald Duman

75
Q

Depression was believed to be caused by downregulation of….. and increase of…..

A

Monoamine, autoreceptor activity

76
Q

What is the series of cellular events that BDNF is dependent upon?

A

1) There is an influx of Calcium upon the activation of monoamine metabotropic receptors.
2) Calcium then activates second messengers
3) Second messengers (CREB) which regulate the transcription of BDNF from the cell’s DNA is activated
4) BDNF is increased/activated
5) AKA… Calcium starts the party, cAMP goes up, PKA goes up, CREB goes up, BDNF goes up, and depression goes down.