systemic lupus erythematosus Flashcards
clinical problems
joint pain and swelling
rash
cough
hair problems
chest pain
abnormal blood results
prescribing
when does systemic lupus erythematosus present
late teens and around 40s/50s
is SLE more severe in people with particular ethnic backgrounds
yes
causes of SLE
genetic predisposition
hormonal factors i.e estrogen exposure
immuological factors i.e infection
mechanism
immune system starts behaving abnormally
deregulated apoptosis so cell contetns arent cleared as effectively
cell contents floating around
immune system recognises as antigens and so attack them
b cells and t cells produce antidbodies agaisnt these antigens
complexes form and get deposited in blood vessel walls
activation of complement attracting leucocytes s to site of injury causing inflammation leading to scarring and necrosis
involvements
skin
joints
haematological system
inflammatory arthirits
neurlogical issues; delirium, psychosis, seizure,headache
renal system
serositis; pleura and pericardium
skin involvements in SLE
mouth ulcers
nasal ulcers
non scarring alopecia
sparing around the nose
renal system involvement
proteinuria >0.5g in 24hrs
biopsy porvn nephritis
autoantibodies in SLE
ANA
dsDNA
APLS
Anti-ro
most specific antibody in SLE
dsDNA
anti double sttranded DNA antibody
present in 60%
not really present in any other situation
sensitive but not so specific autoantibody in SLE
ANA
cant really have lupus if dont have
Autoantibody associated with recurrent miscarriages
Antiphospholipid antibody
what auto antibody has assoviated risk with blood clots
APLS
management of SLE
sun protection
hydroxychloroquine; helps things from getting worse
minimise steroid use
monitor disease using SLEDAI score
what are connective tissue diseases
not diseases of connective tissue
conditions associated with over activity of the imune system
evolve over years/ months leading to organ failure
