Drugs Flashcards
corticosteroid use
inflammatory arthritis
polymyalgia rheumatica/GCA
vasculitis
other biologics
rituximab
tolizumab
examples of common Anti-tnfs
infliximab
adulimumab
anti tnf indications
Rheumatoid arthritis
psoriatic arthritis
ankylosing spondylitis
risks of anti-tnfs
malignancy risk increased
infection
contraindications of anti tnfs
pulmonary fibrosis and heart failure
first line gout prophylaxis
allopurinol
what drug if allopurinol is contraindcated
febuxoslat
moa of gout prophylaxis
xanthine oxidase inhibitors
contraindications of gout prophylaxis
allopurinol- renal impairemnt
febuxoslat- ischaemic heart disease
what to take for first 6 weeks of gout prophylaxis
NSAIDSA
second line bisphosphonates if oral contra
IV desunomab
zelodronic acid
first line DMARD
Methoterxate
what is methotrexate prescirbe din
RA, psoriatic arthritis
CTD, vasculitis
teratogen
methotrexate
MOA of methotrexate
dihydrofolate reductase inhibitor
what is methotrexate co prescribed with
folic acid as it is a folate antagonist
what does methotrexate impair
dna and rna synthesis
arrests cell cycle in s phase
side effecst of methotrexate
diarrhoea, mouth ulcers, rash, hepatitis/ cirrhosis
NSAID examples
brufen, dicloflenac , naproxen
MOA of NSAIDS
cox enzyme inhibitors
side effects of NSAIDS
stomach ulcers, bleeding
what do COX enzymes play a role in
producing prostaglandins, prostacyclins and thromboxane
NSAIDS prescirbed in…
inflammatory arthritis
mechanical pain
pleuritic/ pericardial pain
leflunomide
similar to methotrexate
pyrimidine synthesis inhibitor
long half life so requires wash out
what is often given with methotrexate besides folic acid in inflammatory arthritis
sulfasalazine
first line drug for osteoporosis and pagets
bisphosphonates
use of bisphosphonates
prevent bone loss
example of a bisphosphonate
alendronate
First line in SLE
hydroxychloroquine
what is hydroxycholorquine used in
sjorgens , CTD- sle
what does being on hydroxychloroquine require annually
optometry checkups as it can cause retinopathy
use of hydroxychloroquine
slows disease progression
manages symptoms
