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MSK > Drugs > Flashcards

Drugs Flashcards

1
Q

corticosteroid use

A

inflammatory arthritis
polymyalgia rheumatica/GCA
vasculitis

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2
Q

other biologics

A

rituximab
tolizumab

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3
Q

examples of common Anti-tnfs

A

infliximab
adulimumab

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4
Q

anti tnf indications

A

Rheumatoid arthritis
psoriatic arthritis
ankylosing spondylitis

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5
Q

risks of anti-tnfs

A

malignancy risk increased
infection

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6
Q

contraindications of anti tnfs

A

pulmonary fibrosis and heart failure

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7
Q

first line gout prophylaxis

A

allopurinol

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8
Q

what drug if allopurinol is contraindcated

A

febuxoslat

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9
Q

moa of gout prophylaxis

A

xanthine oxidase inhibitors

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10
Q

contraindications of gout prophylaxis

A

allopurinol- renal impairemnt
febuxoslat- ischaemic heart disease

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11
Q

what to take for first 6 weeks of gout prophylaxis

A

NSAIDSA

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12
Q

second line bisphosphonates if oral contra

A

IV desunomab
zelodronic acid

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13
Q

first line DMARD

A

Methoterxate

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14
Q

what is methotrexate prescirbe din

A

RA, psoriatic arthritis
CTD, vasculitis

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15
Q

teratogen

A

methotrexate

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16
Q

MOA of methotrexate

A

dihydrofolate reductase inhibitor

17
Q

what is methotrexate co prescribed with

A

folic acid as it is a folate antagonist

18
Q

what does methotrexate impair

A

dna and rna synthesis
arrests cell cycle in s phase

19
Q

side effecst of methotrexate

A

diarrhoea, mouth ulcers, rash, hepatitis/ cirrhosis

20
Q

NSAID examples

A

brufen, dicloflenac , naproxen

21
Q

MOA of NSAIDS

A

cox enzyme inhibitors

22
Q

side effects of NSAIDS

A

stomach ulcers, bleeding

23
Q

what do COX enzymes play a role in

A

producing prostaglandins, prostacyclins and thromboxane

24
Q

NSAIDS prescirbed in…

A

inflammatory arthritis
mechanical pain
pleuritic/ pericardial pain

25
Q

leflunomide

A

similar to methotrexate
pyrimidine synthesis inhibitor
long half life so requires wash out

26
Q

what is often given with methotrexate besides folic acid in inflammatory arthritis

A

sulfasalazine

27
Q

first line drug for osteoporosis and pagets

A

bisphosphonates

28
Q

use of bisphosphonates

A

prevent bone loss

29
Q

example of a bisphosphonate

A

alendronate

30
Q

First line in SLE

A

hydroxychloroquine

31
Q

what is hydroxycholorquine used in

A

sjorgens , CTD- sle

32
Q

what does being on hydroxychloroquine require annually

A

optometry checkups as it can cause retinopathy

33
Q

use of hydroxychloroquine

A

slows disease progression
manages symptoms

34
Q
A

MSK (45 decks)

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