Drugs

Question 1

corticosteroid use

Answer 1

inflammatory arthritis
polymyalgia rheumatica/GCA
vasculitis

Question 2

other biologics

Answer 2

rituximab
tolizumab

Question 3

examples of common Anti-tnfs

Answer 3

infliximab
adulimumab

Question 4

anti tnf indications

Answer 4

Rheumatoid arthritis
psoriatic arthritis
ankylosing spondylitis

Question 5

risks of anti-tnfs

Answer 5

malignancy risk increased
infection

Question 6

contraindications of anti tnfs

Answer 6

pulmonary fibrosis and heart failure

Question 7

first line gout prophylaxis

Answer 7

allopurinol

Question 8

what drug if allopurinol is contraindcated

Answer 8

febuxoslat

Question 9

moa of gout prophylaxis

Answer 9

xanthine oxidase inhibitors

Question 10

contraindications of gout prophylaxis

Answer 10

allopurinol- renal impairemnt
febuxoslat- ischaemic heart disease

Question 11

what to take for first 6 weeks of gout prophylaxis

Answer 11

NSAIDSA

Question 12

second line bisphosphonates if oral contra

Answer 12

IV desunomab
zelodronic acid

Question 13

first line DMARD

Answer 13

Methoterxate

Question 14

what is methotrexate prescirbe din

Answer 14

RA, psoriatic arthritis
CTD, vasculitis

Question 15

teratogen

Answer 15

methotrexate

Question 16

MOA of methotrexate

Answer 16

dihydrofolate reductase inhibitor

Question 17

what is methotrexate co prescribed with

Answer 17

folic acid as it is a folate antagonist

Question 18

what does methotrexate impair

Answer 18

dna and rna synthesis
arrests cell cycle in s phase

Question 19

side effecst of methotrexate

Answer 19

diarrhoea, mouth ulcers, rash, hepatitis/ cirrhosis

Question 20

NSAID examples

Answer 20

brufen, dicloflenac , naproxen

Question 21

MOA of NSAIDS

Answer 21

cox enzyme inhibitors

Question 22

side effects of NSAIDS

Answer 22

stomach ulcers, bleeding

Question 23

what do COX enzymes play a role in

Answer 23

producing prostaglandins, prostacyclins and thromboxane

Question 24

NSAIDS prescirbed in…

Answer 24

inflammatory arthritis
mechanical pain
pleuritic/ pericardial pain

Question 25

leflunomide

Answer 25

similar to methotrexate pyrimidine synthesis inhibitor long half life so requires wash out

Question 26

what is often given with methotrexate besides folic acid in inflammatory arthritis

Answer 26

sulfasalazine

Question 27

first line drug for osteoporosis and pagets

Answer 27

bisphosphonates

Question 28

use of bisphosphonates

Answer 28

prevent bone loss

Question 29

example of a bisphosphonate

Answer 29

alendronate

Question 30

First line in SLE

Answer 30

hydroxychloroquine

Question 31

what is hydroxycholorquine used in

Answer 31

sjorgens , CTD- sle

Question 32

what does being on hydroxychloroquine require annually

Answer 32

optometry checkups as it can cause retinopathy

Question 33

use of hydroxychloroquine

Answer 33

slows disease progression manages symptoms