spondyloarthropathies Flashcards

1
Q

clinical problems associated with spondyloarthritis

A

back pain
joint pain/swelling
red/painful eye
rash

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2
Q

what is spondyloarthritis

A

A group of related but distinct conditions with similar clinical features including chronic back pain due to spinal inflammation, peripheral arthritis, enthesitis and dactylitis

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3
Q

conditions involved

A

Ankylosing spondylitis/Axial Spondyloarthropathy
Psoriatic Arthritis
Enteropathic Arthritis
Reactive Arthritis

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4
Q

hLA-B27

A

associated with ankylosing spondylitis

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5
Q

mechanical back pain features

A

Worsened by activity
Improved with rest
Worse at end of day
Onset at any age
Variable speed of onset, may be acute

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6
Q

inflammatory back pain features

A

Improved by activity but not with rest
Associated with prolonged (>30min) morning stiffness
Responds well to NSAIDs
Insidious onset
Wakes patient in second half of the night
Age of onset <40 (some say <35)

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7
Q

enthesitis

A

inflammation where the tendons/ligaments insert into bone

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8
Q

dactilytis

A

inflammation of the tendons and entheses throughout the digit; entire digit swells
in fingers/ toes

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9
Q

state shared features of spondyloarthropathies

A

enthesitis
dactylitis
joint inflammation

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10
Q

shared extra articular features

A

occular inflammation; anterior uveitis, conjunctivitis
mucocutaneous lesions
cardiac; aortic incompetence, heart blcok

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11
Q

ankylosing spondyloarthritis

A

Chronic inflammatory disease of the axial skeleton that leads to partial or even complete fusion and rigidity of the spine

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12
Q

which gender is ankylosing spondy more common in

A

men

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13
Q

what happens to a spine with ankylosing spondylitis

A

syndesmophyte; fusion of the vertebrae

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14
Q

diagnosis of ankylosing spondylitis

A

history and exam
bloods; crop and hla-b27
xrays and mri

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15
Q

what is seen on xray of ankyosing

A

Syndesmophytes
Marginal Ossification
Bamboo spine
Shiny corners
Sacroiliac joint erosions
Sacroiliac joint fusion

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16
Q

what is seen on mri in akylosing

A

Bone oedema
Sacroiliac joints
Vertebrae- shiny corners

17
Q

complications of ankylosing

A

osteoporosis and reduced spinal flexibility
Ventilatory impairment
Aortic Regurgitation
Heart Block
Amyloidosis

18
Q

what is psoriatic arthritis

A

Seronegative inflammatory arthropathy occurring in patients with psoriasis

19
Q

clinical features of psoriatic arthritis

A

peripheral joint involvement
axial involvement
nail involvement
dactylitis
enthesitis
extra articular features ; eye disease and psoriasis

20
Q

reactive arthritis

A

Seronegative, sterile, systemic disease characterised primarily by an inflammatory arthritis induced by infective illness
no infection in joint itself

21
Q

when does reactive arthritis occur

A

1-4 weeks after infection

22
Q

triad of reactive arthritis

A

urethritis
conjunctivitis
arthritis

23
Q

enteropathic arthritis

A

Seronegative arthritis associated with inflammatory bowel disease

24
Q

management of spondyloarthritis

A

Physiotherapy
Particularly important in sacroiliitis/spondylitis
Occupational therapy
Podiatry
Orthotics

NSAIDs
Corticosteroids/Joint injections
Initial bridging therapy
Topical steroid eyedrops- Uveitis
Disease Modifying Anti-Rheumatic Drugs
Methotrexate, Sulfasalazine, Leflunomide
Methotrexate also a treatment for uveitis
biologics