sjogrens syndrome Flashcards
what is it
dryness in different parts of the body due to it ffecting the exocrine glands
which gender has a hgiher prevalance
women
which type of hypersensitivty reaction is sjogrens
type IV
symptoms
reduced tear secretions
keratoconjunctivitys; dry gritty eyes that may appear red
dryness of the mouth that may cause difficulty swallowing
vaginal dryness
extraglandular features
systemic upset
arthritis
raynauds
cutaneous vasculitis
signs
bilateral carotid gland enlargement
dental caries
oral candidiasis
fissured tongue
which auto antibody is usually raised but isnt specific
ANA
which auto antibodies are more specific for sjogrens
anti ro and anti la
shirmers test
demonstratres reduced tear production using a strip of filet paper on lower eyelid with wetting. of <5mm being positive
diagnosis
salivary gland biopsy showing lymphocytic infiltrates
management for sjogrens
symptom control - tear and salivary replacement for dryness
excersize for pain and fatigue
hydroxychloroquine can sometimes help with arthralgia and fatigue
complications
increases risk of lymphoma in affceted glands - b cell lmyphoma i particular
which immunoglobulin is raised in sjogrens
IgG
how to treat fatigue and arthralgia in sjogrens
hydroxychloroquine
